Matches in SemOpenAlex for { <https://semopenalex.org/work/W2493457377> ?p ?o ?g. }
- W2493457377 abstract "Abstract: To identify new approaches to enhance innate immunity to bacterial pneumonia, we investigated the natural experiment of gender differences in resistance to infections. Female and estrogen-treated male mice show greater resistance to pneumococcal pneumonia, seen as greater bacterial clearance, diminished lung inflammation and better survival. In vitro, lung macrophages from female mice and humans show better killing of ingested bacteria. Inhibitors and genetically altered mice identify a critical role for estrogen-mediated activation of lung macrophage nitric oxide synthase-3 (NOS3). Epidemiologic data show decreased hospitalization for pneumonia in women receiving estrogen or statins (known to activate NOS3). Pharmacologic targeting of NOS3 with statins or another small-molecule compound (AVE3085) enhanced macrophage bacterial killing, improved bacterial clearance and increased host survival in both primary and secondary (post-influenza) pneumonia. The data identify a novel mechanism for host defense via NOS3 and suggest a potential therapeutic strategy to reduce secondary bacterial pneumonia after influenza. Impact statement: Impact statement: Activation of lung macrophage nitric oxide synthase-3 improves both bacterial clearance and outcome in primary and secondary pneumonia models. Competing interests:" @default.
- W2493457377 created "2016-08-23" @default.
- W2493457377 creator A5029081581 @default.
- W2493457377 creator A5041924589 @default.
- W2493457377 date "2014-01-01" @default.
- W2493457377 modified "2023-09-23" @default.
- W2493457377 title "FOR PEER REVIEW - CONFIDENTIAL Female Resistance to Pneumonia Identifies Lung Macrophage Nitric Oxide Synthase-3 as a Female Resistance to Pneumonia Identifies Lung Macrophage Nitric Oxide Synthase-3 as a Therapeutic Target" @default.
- W2493457377 cites W1531133799 @default.
- W2493457377 cites W1781589933 @default.
- W2493457377 cites W1949707070 @default.
- W2493457377 cites W1966120931 @default.
- W2493457377 cites W1970863319 @default.
- W2493457377 cites W1972724464 @default.
- W2493457377 cites W1984760712 @default.
- W2493457377 cites W1997096154 @default.
- W2493457377 cites W2003085539 @default.
- W2493457377 cites W2004175200 @default.
- W2493457377 cites W2019586445 @default.
- W2493457377 cites W2021992999 @default.
- W2493457377 cites W2024085541 @default.
- W2493457377 cites W2044451441 @default.
- W2493457377 cites W2063449352 @default.
- W2493457377 cites W2063563210 @default.
- W2493457377 cites W2068233691 @default.
- W2493457377 cites W2071338523 @default.
- W2493457377 cites W2074572884 @default.
- W2493457377 cites W2103258561 @default.
- W2493457377 cites W2105413159 @default.
- W2493457377 cites W2109679166 @default.
- W2493457377 cites W2113120391 @default.
- W2493457377 cites W2117364271 @default.
- W2493457377 cites W2120579640 @default.
- W2493457377 cites W2124764241 @default.
- W2493457377 cites W2126106976 @default.
- W2493457377 cites W2128394438 @default.
- W2493457377 cites W2134139253 @default.
- W2493457377 cites W2135838179 @default.
- W2493457377 cites W2138396364 @default.
- W2493457377 cites W2139525991 @default.
- W2493457377 cites W2168805867 @default.
- W2493457377 cites W338038585 @default.
- W2493457377 hasPublicationYear "2014" @default.
- W2493457377 type Work @default.
- W2493457377 sameAs 2493457377 @default.
- W2493457377 citedByCount "0" @default.
- W2493457377 crossrefType "journal-article" @default.
- W2493457377 hasAuthorship W2493457377A5029081581 @default.
- W2493457377 hasAuthorship W2493457377A5041924589 @default.
- W2493457377 hasConcept C126322002 @default.
- W2493457377 hasConcept C136449434 @default.
- W2493457377 hasConcept C202751555 @default.
- W2493457377 hasConcept C203014093 @default.
- W2493457377 hasConcept C2776345407 @default.
- W2493457377 hasConcept C2776914184 @default.
- W2493457377 hasConcept C2777164284 @default.
- W2493457377 hasConcept C2777622882 @default.
- W2493457377 hasConcept C2777714996 @default.
- W2493457377 hasConcept C2777914695 @default.
- W2493457377 hasConcept C2778012055 @default.
- W2493457377 hasConcept C2779244956 @default.
- W2493457377 hasConcept C519581460 @default.
- W2493457377 hasConcept C55493867 @default.
- W2493457377 hasConcept C71924100 @default.
- W2493457377 hasConcept C86803240 @default.
- W2493457377 hasConcept C8891405 @default.
- W2493457377 hasConcept C89423630 @default.
- W2493457377 hasConceptScore W2493457377C126322002 @default.
- W2493457377 hasConceptScore W2493457377C136449434 @default.
- W2493457377 hasConceptScore W2493457377C202751555 @default.
- W2493457377 hasConceptScore W2493457377C203014093 @default.
- W2493457377 hasConceptScore W2493457377C2776345407 @default.
- W2493457377 hasConceptScore W2493457377C2776914184 @default.
- W2493457377 hasConceptScore W2493457377C2777164284 @default.
- W2493457377 hasConceptScore W2493457377C2777622882 @default.
- W2493457377 hasConceptScore W2493457377C2777714996 @default.
- W2493457377 hasConceptScore W2493457377C2777914695 @default.
- W2493457377 hasConceptScore W2493457377C2778012055 @default.
- W2493457377 hasConceptScore W2493457377C2779244956 @default.
- W2493457377 hasConceptScore W2493457377C519581460 @default.
- W2493457377 hasConceptScore W2493457377C55493867 @default.
- W2493457377 hasConceptScore W2493457377C71924100 @default.
- W2493457377 hasConceptScore W2493457377C86803240 @default.
- W2493457377 hasConceptScore W2493457377C8891405 @default.
- W2493457377 hasConceptScore W2493457377C89423630 @default.
- W2493457377 hasLocation W24934573771 @default.
- W2493457377 hasOpenAccess W2493457377 @default.
- W2493457377 hasPrimaryLocation W24934573771 @default.
- W2493457377 hasRelatedWork W1918446975 @default.
- W2493457377 hasRelatedWork W1941070784 @default.
- W2493457377 hasRelatedWork W1964819020 @default.
- W2493457377 hasRelatedWork W1984049287 @default.
- W2493457377 hasRelatedWork W2010704108 @default.
- W2493457377 hasRelatedWork W2029434160 @default.
- W2493457377 hasRelatedWork W2031200605 @default.
- W2493457377 hasRelatedWork W2065091721 @default.
- W2493457377 hasRelatedWork W2123556794 @default.
- W2493457377 hasRelatedWork W2148441972 @default.
- W2493457377 hasRelatedWork W2152359588 @default.
- W2493457377 hasRelatedWork W2160810031 @default.
- W2493457377 hasRelatedWork W2161845623 @default.