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- W2493470167 abstract "In this chapter we provide a partial history of randomized controlled trials (RCTs) as they have been applied within the HIV field in pursuit of prevention technologies. These RCTs are mostly prior to pre-exposure prophylactics (PrEP) and the account presented here is meant to contextualize our main object of study, PrEP, and particularly the controversies that surrounded the first round of PrEP RCTs. Central to the story of the early PrEP trials as told by various interested parties (for example, activists, trialists) was the question of whether these trials were devised in what amounts to an unethical manner. Also at stake in these debates was whether these concerns could be equally applied to other HIV prevention trials. As we shall see, some actors have been adamant that the PrEP trials in which they were involved were ethical; others have maintained that the requirements to inform and protect participants were not met; and a third group have questioned why the early PrEP trials provoked controversy when, in their view, issues of protecting participants were not so different to other prevention trials. Informing all three positions are some key assumptions that underpin the rationale for clinical trials — a rationale in which RCTs come to be regarded as the ‘gold standard’ for achieving evidence-based research within the HIV field." @default.
- W2493470167 created "2016-08-23" @default.
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- W2493470167 date "2013-01-01" @default.
- W2493470167 modified "2023-09-23" @default.
- W2493470167 title "A Brief and Partial History of Randomized Controlled Trials (RCTs) in the Context of HIV Prevention and Treatment" @default.
- W2493470167 doi "https://doi.org/10.1057/9781137316677_2" @default.
- W2493470167 hasPublicationYear "2013" @default.
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