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• W2493485297 abstract "Menopause is associated with major changes in several endocrine systems, not the least of which is the growth hormone/insulin-like growth factor-I (GH/IGF-I) axis. There is very strong evidence that growth hormone and insulin-like growth factor-I are essential for maintaining homeostatic balance in the skeleton and other tissues over the lifetime of an individual. IGFs are one of several coupling factors that link bone resorption to bone formation, thereby maintaining adult bone mass. IGF-I also mediates linear growth and acts in an endocrine manner to modulate growth hormone activity in adolescence and during most stages of adult life. More importantly, emerging data suggest that IGF-I expression is heritable, and that the absolute levels of serum IGF-I can affect the expression of several disorders of the menopausal period. On balance, there can be little debate that the IGFs are essential growth factors for the proper function of many tissues. However, more longitudinal studies will be needed to confirm causal relationships between changes in circulating IGF-I and bone mineral density, breast cancer, and heart disease. The therapeutic role of GH in modulating changes in postmenopausal tissues also remains to be determined. But, there are clearly effects from HRT that are mediated through the IGF regulatory system. Hence, the interaction between gonadal steroids and the growth hormone IGF-I axis will continue to remain an area of intense investigations." @default.
• W2493485297 created "2016-08-23" @default.
• W2493485297 creator A5047044979 @default.
• W2493485297 date "2000-01-01" @default.
• W2493485297 modified "2023-09-26" @default.
• W2493485297 title "The Growth Hormone IGF-I Axis and Menopause" @default.
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• W2493485297 doi "https://doi.org/10.1016/b978-012453790-3/50019-6" @default.
• W2493485297 hasPublicationYear "2000" @default.
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