FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2493610001> ?p ?o ?g. }

• W2493610001 endingPage "784" @default.
• W2493610001 startingPage "776" @default.
• W2493610001 abstract "The natural product tetramethylpyrazine (TMP) and resveratrol have a variety of biologic activities, including anti-cancer effects. However the pharmacological function of CSTMP (a newly designed and synthesized TMP and resveratrol derivative) in cancer have not been elucidated.In RPMI8226 cells, the cytotoxic effects and apoptosis were detected by MTT and Double staining for Annexin V-FITC and propidium iodide (PI). The protein and mRNA expression levels were detected by Real Time PCR and Western blot, respectively. The localization of cleaved caspase-12 was evaluated by immunofluorescent staining. The activation of caspase were measured by colorimetric assays and Western blot.CSTMP showed significantly cytotoxic effects and induced apoptosis in RPMI8226 cells. Caspase activation, Cytochrome c release and Bax, Bcl-2 and Bcl-XL levels analyses demonstrated that the anti-cancer effect of CSTMP in RPMI8226 cells was mediated by promoting caspase- and mitochondria-dependent apoptosis. In addition, CSTMP induced the increased expression of endoplasmic reticulum (ER) stress related proteins (CHOP, GRP78, GRP94 and cleaved caspase-12) and the activation of multiple branches of ER stress transducers (PERK-eIF2α, IRE1α and ATF6). Moreover, knockdown of CHOP by siRNA markedly inhibited CSTMP-induced cytotoxic effects, caspases activity and mitochondrial dysfunction in RPMI8226 cells.Our results indicated that CSTMP could induce apoptosis and mitochondrial dysfunction in RPMI8226 cells via CHOP-dependent ER stress." @default.
• W2493610001 created "2016-08-23" @default.
• W2493610001 creator A5004217313 @default.
• W2493610001 creator A5006121037 @default.
• W2493610001 creator A5036726873 @default.
• W2493610001 creator A5049119878 @default.
• W2493610001 creator A5060798667 @default.
• W2493610001 creator A5073969669 @default.
• W2493610001 creator A5074441691 @default.
• W2493610001 creator A5075693356 @default.
• W2493610001 creator A5088144880 @default.
• W2493610001 date "2016-10-01" @default.
• W2493610001 modified "2023-09-23" @default.
• W2493610001 title "CSTMP induces apoptosis and mitochondrial dysfunction in human myeloma RPMI8226 cells via CHOP-dependent endoplasmic reticulum stress" @default.
• W2493610001 cites W1540615713 @default.
• W2493610001 cites W1586446199 @default.
• W2493610001 cites W1972868748 @default.
• W2493610001 cites W1983688352 @default.
• W2493610001 cites W1995645692 @default.
• W2493610001 cites W2003362321 @default.
• W2493610001 cites W2006536349 @default.
• W2493610001 cites W2011203698 @default.
• W2493610001 cites W2024272604 @default.
• W2493610001 cites W2030351477 @default.
• W2493610001 cites W2034213169 @default.
• W2493610001 cites W2037820481 @default.
• W2493610001 cites W2048975837 @default.
• W2493610001 cites W2061086872 @default.
• W2493610001 cites W2069924169 @default.
• W2493610001 cites W2070124969 @default.
• W2493610001 cites W2083344033 @default.
• W2493610001 cites W2089198803 @default.
• W2493610001 cites W2100347985 @default.
• W2493610001 cites W2139568257 @default.
• W2493610001 cites W2142861949 @default.
• W2493610001 cites W2294593089 @default.
• W2493610001 cites W2315469249 @default.
• W2493610001 cites W2408475944 @default.
• W2493610001 cites W4252175385 @default.
• W2493610001 cites W4256495376 @default.
• W2493610001 doi "https://doi.org/10.1016/j.biopha.2016.07.045" @default.
• W2493610001 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27490778" @default.
• W2493610001 hasPublicationYear "2016" @default.
• W2493610001 type Work @default.
• W2493610001 sameAs 2493610001 @default.
• W2493610001 citedByCount "21" @default.
• W2493610001 countsByYear W24936100012017 @default.
• W2493610001 countsByYear W24936100012018 @default.
• W2493610001 countsByYear W24936100012019 @default.
• W2493610001 countsByYear W24936100012020 @default.
• W2493610001 countsByYear W24936100012021 @default.
• W2493610001 countsByYear W24936100012022 @default.
• W2493610001 countsByYear W24936100012023 @default.
• W2493610001 crossrefType "journal-article" @default.
• W2493610001 hasAuthorship W2493610001A5004217313 @default.
• W2493610001 hasAuthorship W2493610001A5006121037 @default.
• W2493610001 hasAuthorship W2493610001A5036726873 @default.
• W2493610001 hasAuthorship W2493610001A5049119878 @default.
• W2493610001 hasAuthorship W2493610001A5060798667 @default.
• W2493610001 hasAuthorship W2493610001A5073969669 @default.
• W2493610001 hasAuthorship W2493610001A5074441691 @default.
• W2493610001 hasAuthorship W2493610001A5075693356 @default.
• W2493610001 hasAuthorship W2493610001A5088144880 @default.
• W2493610001 hasConcept C104317684 @default.
• W2493610001 hasConcept C139447449 @default.
• W2493610001 hasConcept C153911025 @default.
• W2493610001 hasConcept C158617107 @default.
• W2493610001 hasConcept C185592680 @default.
• W2493610001 hasConcept C190283241 @default.
• W2493610001 hasConcept C2775934118 @default.
• W2493610001 hasConcept C2776415932 @default.
• W2493610001 hasConcept C2778997996 @default.
• W2493610001 hasConcept C2779725641 @default.
• W2493610001 hasConcept C2780783641 @default.
• W2493610001 hasConcept C2781331208 @default.
• W2493610001 hasConcept C28859421 @default.
• W2493610001 hasConcept C31573885 @default.
• W2493610001 hasConcept C502942594 @default.
• W2493610001 hasConcept C54458228 @default.
• W2493610001 hasConcept C55493867 @default.
• W2493610001 hasConcept C67705224 @default.
• W2493610001 hasConcept C86803240 @default.
• W2493610001 hasConcept C88634738 @default.
• W2493610001 hasConcept C95444343 @default.
• W2493610001 hasConceptScore W2493610001C104317684 @default.
• W2493610001 hasConceptScore W2493610001C139447449 @default.
• W2493610001 hasConceptScore W2493610001C153911025 @default.
• W2493610001 hasConceptScore W2493610001C158617107 @default.
• W2493610001 hasConceptScore W2493610001C185592680 @default.
• W2493610001 hasConceptScore W2493610001C190283241 @default.
• W2493610001 hasConceptScore W2493610001C2775934118 @default.
• W2493610001 hasConceptScore W2493610001C2776415932 @default.
• W2493610001 hasConceptScore W2493610001C2778997996 @default.
• W2493610001 hasConceptScore W2493610001C2779725641 @default.
• W2493610001 hasConceptScore W2493610001C2780783641 @default.
• W2493610001 hasConceptScore W2493610001C2781331208 @default.
• W2493610001 hasConceptScore W2493610001C28859421 @default.
• W2493610001 hasConceptScore W2493610001C31573885 @default.

• next