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- W2493619044 abstract "Knowledge of cross-reactivity between foods is useful so that potentially cross-reactive allergens can be avoided in diet trials.To evaluate allergenic cross-reactivity in related foods.Sera from 469 dogs with suspected adverse food reactions.An IgE-based serological assay using 19 food allergens was performed in 469 dogs. Pairwise comparisons were used to calculate the odds ratios (ORs) for each food pair, with significance at P < 0.0002 by Holm-Bonferroni correction, both in all 469 dogs and in the 261 of 469 dogs with at least one positive reaction. One-way ANOVA with Tukey's post hoc tests (significance at P < 0.05) were used to test for differences between mean logE ORs in different food groups. Inhibition enzyme-linked immunosorbent assays (ELISAs) were performed to assess allergenic cross-reactivity between beef, lamb and cow's milk.Significant associations were observed between both related and unrelated food pairs. Associations were, however, more frequent and stronger among related than unrelated foods. In all 469 dogs, 38 of 43 related food pairs were significantly associated [mean (SD) logE OR 3.4 (0.9)] compared with 79 of 128 unrelated pairs [2.7 (1.0)], P < 0.0002. In positive dogs, 32 of 43 related pairs were significantly associated [2.7 [1.0)] compared with 49 of 128 unrelated pairs [1.8 (1.0)], P < 0.0002. Inhibition ELISAs confirmed the presence of cross-reactive IgE-binding epitopes in beef, lamb and cow's milk.The results suggest that related and potentially cross-reactive foods should be avoided in elimination diets." @default.
- W2493619044 created "2016-08-23" @default.
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- W2493619044 date "2016-07-18" @default.
- W2493619044 modified "2023-10-01" @default.
- W2493619044 title "Co-sensitization and cross-reactivity between related and unrelated food allergens in dogs - a serological study" @default.
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- W2493619044 doi "https://doi.org/10.1111/vde.12335" @default.
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