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- W2493664593 abstract "Arterial blood pressure (BP), heart rate (HR) and plasma concentration of norepinephrine (NE), epinephrine (EPI), dopamine (DA) and dopamine-s-hydroxylase (DBH) were measured in ten normal and ten familial dysautonomic subjects just after 15 minutes recumbent, 1 minute, and 10 minutes standing. The mean BP in the supine position for the familial dysautonomic patient was higher than that of the normal (p<0.01). The BP decreased significantly in familial dysautonomic patients after standing for 1 minute, and 10 minutes (p<0.01). In normals, BP did not change on standing. Supine HR of 90 in familial dysautonomic patients was significantly higher than HR of 68 in normals (p<0.02). Standing HR’s, however, did not differ in inter- and intra-group comparisons. In familial dysautonomic patients the mean supine NE correlated with changes in mean BP and was higher than normal values of NE. After standing, the concentrations of NE and DBH increased significantly in controls (p<0.05) but did not change in familial dysautonomic patients. Concentrations of EPI and DA, however, did not change significantly in either group. Norepinephrine release correlated with hypertensive and hypotensive episodes in familial dysautonomic patients." @default.
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- W2493664593 date "1981-01-01" @default.
- W2493664593 modified "2023-09-30" @default.
- W2493664593 title "Regulatory dysfunction of tyrosine hydroxylase and dopamine-ß-Hydroxylase in familial dysautonomia" @default.
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- W2493664593 doi "https://doi.org/10.1007/978-1-349-06276-8_41" @default.
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