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- W2493722981 abstract "Background Patient-reported outcome measures (PROMs) are becoming increasingly popular in orthopedic surgery. Preoperative and postoperative follow-up often elicit PROMs in the form of generic quality-of-life instruments (e.g., Short Form health survey SF-12 [SF-12]) that can be used in economic evaluation to estimate quality-adjusted life-years (QALYs). However, the timing of postoperative measurement is still under debate. Objectives To explore the timing of postoperative PROMs collection and the implications for bias in QALY estimation for economic evaluation. Methods We compared the accuracy of QALY estimation on the basis of utilities derived from the SF-12 at one of 6 weeks, 3 months, 6 months, and 12 months after total knee arthroplasty, under different methods of interpolation between points. Five years of follow-up data were extracted from the St. Vincent’s Melbourne Arthroplasty Outcomes (SMART) registry (n = 484). The SMART registry collects follow-up PROMs annually and obtained more frequent outcomes on subset of patients (n = 133). Results Postoperative PROM collection at 6 weeks, 6 months, or 12 months biased the estimation of QALY gain from total knee arthroplasty by −41% (95% confidence interval [CI] −59% to −22%), 18% (95% CI 4%–32%), and −8% (95% CI −18% to −2%), respectively. This bias was minimized by collecting PROMs at 3 months postoperatively (6% error; 95% CI −9% to 21%). Conclusions The timing of PROM collection and the interpolation assumptions between measurements can bias economic evaluation. In the case of total knee arthroplasty, we recommend a postoperative measurement at 3 months with linear interpolation between preoperative and postoperative measures. The design of economic evaluations should consider timing and interpolation issues." @default.
- W2493722981 created "2016-08-23" @default.
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- W2493722981 date "2016-12-01" @default.
- W2493722981 modified "2023-10-03" @default.
- W2493722981 title "Using Patient-Reported Outcomes for Economic Evaluation: Getting the Timing Right" @default.
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- W2493722981 doi "https://doi.org/10.1016/j.jval.2016.05.014" @default.
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