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• W2493768531 abstract "C-Prenylated xanthones are pharmacologically attractive specialized metabolites that are distributed in plants and microorganisms. The prenylation of xanthones often contributes to the structural diversity and biological activities of these compounds. However, efficient regiospecific prenylation of xanthones is still challenging. In this study, the regiospecific prenylation of a number of structurally different hydroxyxanthones (3-10) by MaIDT, a plant flavonoid prenyltransferase with substrate flexibility from Morus alba, is demonstrated. Among the enzymatic products, 2-dimethylallyl-1,3,7-trihydroxyxanthone (3a) effectively attenuated glutamate-induced injury in SK-N-SH neuroblastoma cells. These results suggest a potential approach for the synthesis of bioactive prenylated xanthones by a substrate-relaxed flavonoid prenyltransferase." @default.
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• W2493768531 date "2016-07-28" @default.
• W2493768531 modified "2023-09-29" @default.
• W2493768531 title "Regiospecific Prenylation of Hydroxyxanthones by a Plant Flavonoid Prenyltransferase" @default.
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• W2493768531 doi "https://doi.org/10.1021/acs.jnatprod.6b00417" @default.
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