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- W2493772907 abstract "Crosslinking of membrane surface receptors may lead to their segregation into patches and then into a single large aggregate at one pole of the cell. This process is called capping. Here, a novel explanation of such a process is presented in which the membrane is viewed as a supersaturated solution of receptors in the lipid bilayer and the adjacent two aqueous layers. Without a crosslinking agent, a patch of receptors that is less than a certain size cannot stay in equilibrium with the solution and thus should dissolve. Patches greater than a certain size are stable and can, in principle, grow by the precipitation of the remaining dissolved receptors from the supersaturated solution. The task of the crosslinking molecules is to form such stable patches. These considerations are based on a qualitative thermodynamic calculation that takes into account the existence of a boundary tension in a patch (in analogy to the surface ten- sion of a droplet). Thermodynamically, these systems should cap spontaneously after the patches have reached a certain size. But, in practice, such a process can be very slow. A suspension of patches may stay practically stable. The ways in which a cell may abolish this metastable equilibrium and thus achieve capping are considered and possible effects of capping inhibi- tors are discussed." @default.
- W2493772907 created "2016-08-23" @default.
- W2493772907 creator A5081299245 @default.
- W2493772907 date "2016-01-01" @default.
- W2493772907 modified "2023-09-27" @default.
- W2493772907 title "Model for capping of membrane re, boundary surface effects (cap formation/cell surface/cell membrane proteins)" @default.
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- W2493772907 hasPublicationYear "2016" @default.
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