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- W2494006952 abstract "The bacteriostatic activity of a series of substituted trans-3-benzoylacrylic acids has been successfully correlated by Hansch linear free energy relations involving polar and partition substituent constants. The activity—lipophilicity relations for this series closely parallel those found previously for other antibacterial agents, with an ideal lipophilic character for gram-positive cells of 6.1 and, for linear dependence, a slope of 0.7. A polar reaction constant, ρ, of about —0.6 to —0.7 is given. A possible mode of action for these acids and their related substituted cis- and trans-3-benzoyl acrylic acids and esters is discussed as an enzyme-inhibitor interaction." @default.
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- W2494006952 date "1974-08-01" @default.
- W2494006952 modified "2023-09-25" @default.
- W2494006952 title "Structure—Activity Relations" @default.
- W2494006952 doi "https://doi.org/10.1021/ba-1972-0114.ch009" @default.
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