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- W2494268082 abstract "Traditional studies of the mechanism of phototoxicity of psoralens (furocoumarins) have emphasized their photoaddition reactions with DNA. Photooxidation products of furocumarins, although they have been observed in some studies, have been given little attention. By the use of improved extraction and separation techniques, we recently identified a group of salicylaldehyde derivatives from psoralen photooxidation in vitro. The occurrence of these phenolic aldehydes could possibly account for some of the observed photobiological effects now attributed to the parent compounds. Psoralen and 8-methoxypsoralen are quite susceptible to photolysis in polar solvents such as water, giving many cleavage products including aldehydes, carboxylic acids, and hydrogen peroxide. Studies with photolyzed psoralens and isolated photoproducts such as aromatic aldehydes reveal them to be toxic, even in the absence of light, to Xenopus embryos." @default.
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- W2494268082 date "1995-05-05" @default.
- W2494268082 modified "2023-09-27" @default.
- W2494268082 title "Alternative Mechanisms of Psoralen Phototoxicity" @default.
- W2494268082 doi "https://doi.org/10.1021/bk-1995-0616.ch015" @default.
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