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- W2494282274 abstract "The development of next generation sequencing technologies has revolutionized our understanding of how specific genetic events contribute to cancer initiation and progression. Dramatic improvements in instrument design and efficiency, combined with significant cost reductions has permitted a systematic analysis of the mutational landscape in a variety of cancer types. At the same time, a detailed map of the cancer mutanome in individual cancers offers a unique opportunity to develop personalized cancer vaccine strategies targeting neoantigens. Recent studies in both preclinical models and human cancer patients demonstrate that neoantigens (1) are important targets following checkpoint inhibition therapy, (2) have been identified as the target of adoptive T cell therapies, and (3) can be successfully targeted with personalized vaccines. Taken together, these observations provide strong rationale for the clinical translation of personalized cancer vaccines." @default.
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- W2494282274 date "2017-02-01" @default.
- W2494282274 modified "2023-10-17" @default.
- W2494282274 title "Personalized cancer vaccines: Targeting the cancer mutanome" @default.
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- W2494282274 doi "https://doi.org/10.1016/j.vaccine.2016.05.073" @default.
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