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- W2494318518 abstract "The mechanisms by which tumors develop multi-drug resistance are not well understood. Biodynamic imaging (BDI) is a label-free assay that detects phenotypic response of ex vivo tissue to chemotherapeutic drugs. In the current study, we used BDI to measure the response of primary and metastatic ovarian tumors to cisplatin. Xenografts from two human ovarian cancer cell lines, A2780 and SKOV3, were grown orthotopically in the ovaries of nude mice and allowed to metastasize in the peritoneal space. Primary and metastatic tumors were harvested and tested for response to 25 μM cisplatin by using BDI. Sensitivity was assessed through selected response biomarkers. Metastatic tumors of the platinum-sensitive A2780 cell line showed 20% decrease in sensitivity to cisplatin compared with the response of the primary tumors, while the less sensitive SKOV3 tumors exhibited a 6% decrease in response of metastatic vs. primary tumors. In parallel, RNA sequencing profiled primary ovarian and metastatic implants. Differential gene expression was detected in primary tumors vs. metastatic sites. Genes upregulated in metastases include TIMP3, WNT2, OSR1, elastin (SKOV3 tumor model) and MMP1, MMP3, MMP10, MET, EGFR, PDGF-C (A2780 tumor model). The study demonstrates the ability of BDI to detect differences in drug sensitivity between primary and metastatic tumors and provides support for the association of metastasis and chemoresistance in ovarian cancer. Supported by NIH R01 EB016582. Citation Format: Daniel Merrill, Hao Sun, Daniela Matei, Bakhtiyor Yakubov, John Turek, David Nolte. Heterogeneous response to platinum in metastatic ovarian cancer detectable by biodynamic imaging. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 1541." @default.
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- W2494318518 date "2016-07-15" @default.
- W2494318518 modified "2023-09-27" @default.
- W2494318518 title "Abstract 1541: Heterogeneous response to platinum in metastatic ovarian cancer detectable by biodynamic imaging" @default.
- W2494318518 doi "https://doi.org/10.1158/1538-7445.am2016-1541" @default.
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