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- W2494401568 abstract "Publisher Summary This chapter describes the existing micro-scale polarimetry methods and the progress toward the high throughput (HT) micro-scale screening of compounds for optical activity. One application of conventional polarimetry could benefit from smaller volumes and a higher throughput is enantioselective enzyme production monitoring. While enzymes are useful tools, many lack selectivity, and produce poor yields or low enantiomeric excess (ee). In directed evolution of enantioselective enzymes, thousands of mutants are created to find an enzyme that produces superior selectivity for a desired reaction. Enantioselectivity needs to be analyzed in a HT fashion for the directed evolution to be practical. While other techniques show promise along with the progress made toward HT screening, there is still a need of HT polarimeter. The ability to minimize effects of RI changes, reduction of the amount of sample required, and performance of multiple measurements has presented problems for polarimetry for many years. However, there have been improvements made in polarimetry methodologies. The capillary polarimetric detector represents the first polarimeter that allows optical activity determinations to be performed in sample volumes down to the tens of nanoliters. It is also important to note that the sensitivity is not greatly sacrificed by the decrease in volume, which has been a previous limitation in polarimetry methodologies. The system is insensitive to the refractive index(RI) changes, which can also be a hindrance for some polarimeters. Measurements of optically active molecules on a small scale is now possible, providing opportunities for analyses to be performed that were previously impossible because of sample size. An array of capillaries would provide a unique multiplexed nanoliter polarimeter." @default.
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- W2494401568 date "2006-01-01" @default.
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- W2494401568 title "Micro-scale polarimetry" @default.
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- W2494401568 doi "https://doi.org/10.1016/b978-044451669-5/50011-9" @default.
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