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- W2494490349 abstract "Water-soluble derivatives of three kinds of expanded porphyrins (N-fused pentaphyrin, hexaphyrin, and heptaphyrin) were synthesized and their binding ability to G-quadruplex (G4-) DNA was evaluated. The inhibitory effects on enzymatic telomere extension were also investigated together with other tetrapyrrolic porphyrinoids. While expanded porphyrins increased the melting temperature of G4-DNA more effectively than the regular porphyrins, a porphyrin isomer (N-confused porphyrin) showed the highest inhibitory effect on telomerase activity." @default.
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- W2494490349 date "2016-08-01" @default.
- W2494490349 modified "2023-09-27" @default.
- W2494490349 title "Water-soluble porphyrinoids as G-quadruplex binders and telomerase inhibitors" @default.
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- W2494490349 doi "https://doi.org/10.1142/s108842461650053x" @default.
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