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- W2494508405 abstract "he relevance of a particular signaling Similarly, direct interactio pathway or a protein family correlates cellular domain 4 of the t with the number of functions associated ceptor inhibits NOS3 (6). } with it and their physiological and pathoendothelial cells with bra physiological implications. In the case of the ionophore, NOS3 dissocia nitric oxide (NO) signaling pathway and the plexes and becomes actik NO synthases (NOS1-3), their relevance Stimulation of endothelial became also apparent in recent years from kinin or Ca2+ ionophore < the complexity of their regulation. Not only interaction between NOS' are NOS isozymes cofactor-accumulating dependent anion/cation c enzymes but also are associated with a junfurther augment NO proc gle of more than 20 interacting proteins vation of NOS3 after stin (Table 1). These affect both the activity and cular endothelial growth i spatial organization of NO synthesis within in a dynamic reorganizati the cell, and some of these interactions may complexes between NOS' even have functions beyond NO formation. proteins. The early Ca2 Although the mechanisms regulating vation of NOS3 is follo overall NOS activity by increases in Ca2+ or phosphorylation-depende phosphorylation or by expression are quite protein kinase B/Akt (9, well understood, subcellular regulation of kinase A (11). Heat-sh NO formation by binding proteins with re(Hsp90), which binds bot spect to time and place is much more comand the neuronal isoform plex. The first NOS-binding protein disitates CaM-dependent dis covered was calmodulin (CaM) (1). It is binding with caveolin (15) required for electron flux and thus NO interaction between NOS production by all three NOS isoforms. nase B/Akt (16, 17). Effi Other aspects of NOS regulation such as substrate during all this is membrane attachment and activity moduization of the arginine tra lation are also mediated by (often isoformamino acid transporter (C specific) protein-interaction networks. and its direct interaction Moreover, trafficking of NOS within the cell is an important issue, because these interNOS3 Traffic actions are not static. Zimmermann et al. To ensure that all these" @default.
- W2494508405 created "2016-08-23" @default.
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- W2494508405 date "2016-01-01" @default.
- W2494508405 modified "2023-09-27" @default.
- W2494508405 title "There's NO binding like NOS interactions in NO/cGMP sigr" @default.
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