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- W2494631260 endingPage "100" @default.
- W2494631260 startingPage "85" @default.
- W2494631260 abstract "The liver is a highly aerobic organ, and mitochondria occupy about 20% of hepatocellular volume to meet the ATP demands of ureagenesis and many other hepatic functions. Accordingly, disruption of mitochondrial function underlies the toxicity of many hepatotoxicants. Oxidative stress, acetaminophen, fatty acids, and various carboxylic acids promote onset of the mitochondrial permeability transition, which leads to necrotic cell death from ATP depletion and/or apoptosis after cytochrome c release. Disruption of mitochondrial β-oxidation and the carnitine shuttle that imports medium- and long-chain fatty acids into mitochondria is a frequent cause of hepatic steatosis and sometimes more severe hepatic injury. Some hepatotoxicants are cationic and accumulate into mitochondria electrophoretically to high matrix concentrations that inhibit essential enzymes for respiration, β-oxidation, or oxidative phosphorylation. Lastly, antiviral compounds can interfere with replication of mitochondrial DNA, leading to deficiencies of 13 essential proteins of oxidative phosphorylation and a fulminant and irreversible hepatic failure. Overall, hepatic toxicity due to adverse effects on mitochondrial function remains an important cause of drug-induced liver injury." @default.
- W2494631260 created "2016-08-23" @default.
- W2494631260 creator A5035890041 @default.
- W2494631260 date "2013-01-01" @default.
- W2494631260 modified "2023-10-15" @default.
- W2494631260 title "Hepatotoxicity Due to Mitochondrial Injury" @default.
- W2494631260 cites W116341769 @default.
- W2494631260 cites W121254590 @default.
- W2494631260 cites W1429481766 @default.
- W2494631260 cites W1480951384 @default.
- W2494631260 cites W1507410890 @default.
- W2494631260 cites W1518489158 @default.
- W2494631260 cites W1548452718 @default.
- W2494631260 cites W1561608454 @default.
- W2494631260 cites W1605235029 @default.
- W2494631260 cites W177923845 @default.
- W2494631260 cites W1800399702 @default.
- W2494631260 cites W1887119011 @default.
- W2494631260 cites W1948525638 @default.
- W2494631260 cites W1956075528 @default.
- W2494631260 cites W1965306494 @default.
- W2494631260 cites W1966601836 @default.
- W2494631260 cites W1967264163 @default.
- W2494631260 cites W1967537073 @default.
- W2494631260 cites W1967671174 @default.
- W2494631260 cites W1968037013 @default.
- W2494631260 cites W1968332094 @default.
- W2494631260 cites W1972465938 @default.
- W2494631260 cites W1974945118 @default.
- W2494631260 cites W1979590516 @default.
- W2494631260 cites W1980147218 @default.
- W2494631260 cites W1980964573 @default.
- W2494631260 cites W1981280200 @default.
- W2494631260 cites W1981757167 @default.
- W2494631260 cites W1983378578 @default.
- W2494631260 cites W1984111162 @default.
- W2494631260 cites W1985776762 @default.
- W2494631260 cites W1989046593 @default.
- W2494631260 cites W1990895399 @default.
- W2494631260 cites W1991211417 @default.
- W2494631260 cites W1994442108 @default.
- W2494631260 cites W1995069275 @default.
- W2494631260 cites W1995966034 @default.
- W2494631260 cites W1996379134 @default.
- W2494631260 cites W1996738096 @default.
- W2494631260 cites W1996867825 @default.
- W2494631260 cites W1997037955 @default.
- W2494631260 cites W1997224005 @default.
- W2494631260 cites W1997357473 @default.
- W2494631260 cites W1998101020 @default.
- W2494631260 cites W2000014909 @default.
- W2494631260 cites W2000958871 @default.
- W2494631260 cites W2001394100 @default.
- W2494631260 cites W2002652542 @default.
- W2494631260 cites W2003873847 @default.
- W2494631260 cites W2005571058 @default.
- W2494631260 cites W2005883891 @default.
- W2494631260 cites W2008117638 @default.
- W2494631260 cites W2010520981 @default.
- W2494631260 cites W2010766264 @default.
- W2494631260 cites W2011726280 @default.
- W2494631260 cites W2016693012 @default.
- W2494631260 cites W2020202249 @default.
- W2494631260 cites W2025844537 @default.
- W2494631260 cites W2027008357 @default.
- W2494631260 cites W2028689205 @default.
- W2494631260 cites W2028900979 @default.
- W2494631260 cites W2029144840 @default.
- W2494631260 cites W2030804798 @default.
- W2494631260 cites W2032234589 @default.
- W2494631260 cites W2036311455 @default.
- W2494631260 cites W2038481472 @default.
- W2494631260 cites W2038976751 @default.
- W2494631260 cites W2039198845 @default.
- W2494631260 cites W2039510157 @default.
- W2494631260 cites W2040093546 @default.
- W2494631260 cites W2045143928 @default.
- W2494631260 cites W2047963062 @default.
- W2494631260 cites W2048229179 @default.
- W2494631260 cites W2048607634 @default.
- W2494631260 cites W2049773199 @default.
- W2494631260 cites W2052356187 @default.
- W2494631260 cites W2056015556 @default.
- W2494631260 cites W2056309362 @default.
- W2494631260 cites W2056695281 @default.
- W2494631260 cites W2057767639 @default.
- W2494631260 cites W2059320820 @default.
- W2494631260 cites W2060363769 @default.
- W2494631260 cites W2060637877 @default.
- W2494631260 cites W2061905834 @default.
- W2494631260 cites W2062366543 @default.
- W2494631260 cites W2066047552 @default.
- W2494631260 cites W2066571367 @default.
- W2494631260 cites W2067656659 @default.
- W2494631260 cites W2068168221 @default.
- W2494631260 cites W2068630823 @default.
- W2494631260 cites W2068689158 @default.
- W2494631260 cites W2068972164 @default.