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• W2494806298 abstract "Objective: To describe the clinical, behavioral, and cognitive outcomes of an adolescent with Neuromyelitis optica (NMO) and N-methyl D aspartate receptor antibody encephalitis (NMDAR encephalitis). Background: There are rare reports of NMDAR encephalitis and NMO developing in the same adult. Here, we describe an adolescent who experienced both disorders 12 months apart and underwent cognitive testing during her course. Methods: Case report with data from an IRB approved database on pediatric demyelinating disorder Results: An 11 year old girl, born and raised in Anguilla, developed acute disseminated encephalomyelitis (ADEM) and seizures. She was brought to the USA, treated with intravenous (IV) steroids, anticonvulsants, and fully recovered. She returned home, did well socially and in school, but five years later, (9/2012) developed transverse myelitis, received IV steroids and had residual lower extremity increased tone and hyperreflexia. On 8/2013 she presented to the Lourie Center for Pediatric MS) seeking a diagnosis; NMO was confirmed with positive anti-aquaporin serology. Mental status was normal; symbol digit modality test (SDMT) raw score=79 (z score=2.5). She returned home, but came back one month later (9/2013), disoriented, confused and psychotic. She was hospitalized with catatonia. Toxicology screen was negative; neuroimaging abnormalities were unchanged. NMDAR encephalitis was confirmed with positive CSF antibody. On hospitalization her raw score SDMT=14 (z score= -5.0) and Montreal Cognitive Assessment score (MOCA)=17. Following plasmapheresis and rituximab her mental status improved. By (10/2013) raw score SDMT=43 (z score= -1.8); MOCA=25. Two years later, (9/2015); her mental status and behavior were back to her normal baseline: raw score SDMT=84 (z score=1.1), verbal memory on the Rey Auditory Verbal Learning Test raw score=70 (z score=2.5) and visual memory on the Brief Visual Memory Retention Test-Revised raw score=30 (z score=0.29). Conclusions: NMDAR encephalitis can follow pediatric NMO; full recovery of behavioral and cognitive function is possible. Disclosure: Dr. Elgallab has nothing to disclose. Dr. Leigh Elkins Charvet has received personal compensation for activities with Biogen as a consultant. Dr. Belman has nothing to disclose. Dr. Schwarz has nothing to disclose. Dr. Krupp has received licensing and/or royalty fees from Johnson and Johnson, AbbVie, and Grifols." @default.
• W2494806298 created "2016-08-23" @default.
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• W2494806298 date "2016-04-05" @default.
• W2494806298 modified "2023-09-28" @default.
• W2494806298 title "NMDAR Encephalitis in a Patient with NMO: A Double Hit without Cognitive Sequelae Following Treatment (P6.158)" @default.
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