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• W2494896898 abstract "Abstract While 2D models lack physiological relevance, animal models are highly complex and uncontrolled, and often do not mimic the human tumor microenvironment (TME). Therefore, more physiologically relevant engineered tumor models have begun to fill a unique niche in modeling the complex dynamics of the human TME. Advances in biomaterials and microfabrication techniques applied to soft materials have helped to drive a recent resurgence of this field, which has actually been around since spheroid culture models were first introduced decades ago. The varied geometries of microengineered tissues allow for hypotheses concerning a specific aspect of the TME to be efficiently addressed. To facilitate understanding of the importance of these varied 3D systems to cancer biology, we will provide an overview of the general composition and purpose for each of the more common as well as cutting-edge model platforms, including spheroids, microwell arrays, microfluidic tissues, and 3D printed tissues. To date, these models are rarely, if ever, created by two-photon polymerization, but the opportunity for use of two-photon polymerization, and more broadly dynamic manipulation with focused light, in important applications is clear." @default.
• W2494896898 created "2016-08-23" @default.
• W2494896898 creator A5008275970 @default.
• W2494896898 creator A5032531010 @default.
• W2494896898 creator A5091288879 @default.
• W2494896898 date "2016-01-01" @default.
• W2494896898 modified "2023-09-26" @default.
• W2494896898 title "Engineered Microenvironments for Cancer Study" @default.
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