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• W2494935722 abstract "// Kai M. Brown 1,2,3 , Aiqun Xue 3 , Anubhav Mittal 1,2,3 , Jaswinder S. Samra 1,2 , Ross Smith 3 and Thomas J. Hugh 1,2,3 1 Northern Clinical School, University of Sydney, Sydney, New South Wales, Australia 2 Upper GI Surgical Unit, Royal North Shore Hospital and North Shore Private Hospital, Sydney, New South Wales, Australia 3 Cancer Surgery and Metabolism Research Group, The Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, New South Wales, Australia Correspondence to: Kai M. Brown, email: // Keywords : patient-derived xenograft, colorectal cancer, systematic review, PDX, animal model Received : February 07, 2016 Accepted : July 18, 2016 Published : August 10, 2016 Abstract AIMS: We sought to objectively assess the internal and external validity of patient-derived xenograft (PDX) models as a platform in pre-clinical research into colorectal cancer (CRC). Metastatic disease is the most common cause of death from CRC, and despite significant research, the results of current combination chemotherapy and targeted therapies have been underwhelming for most of this patient group. One of the key factors limiting the success of translational CRC research is the biologically inaccurate models in which new therapies are developed. METHODS: We used the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) checklist and SYRCLE (Systematic Review Centre for Laboratory animal Experimentation) guidelines to search Ovid MEDLINE and Embase databases up to July 2015 to identify studies involving PDX models of CRC where the model had been validated across multiple parameters. Data was extracted including host mouse strain, engraftment rate, site of engraftment, donor tumour source and development of metastases in the model. RESULTS: Thirteen articles satisfied the inclusion criteria. There was significant heterogeneity amongst the included studies, but overall the median engraftment rate was high (70%) and PDX models faithfully recapitulated the characteristics of their patient tumours on the microscopic, genetic and functional levels. CONCLUSIONS: PDX models of CRC have a reasonable internal validity and a high external validity. Developments in xenografting technology are broadening the applications of the PDX platform. However, the included studies could be improved by standardising reporting standards and closed following the ARRIVE (Animals in Research: Reporting In Vivo Experiments) guidelines." @default.
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• W2494935722 date "2016-08-10" @default.
• W2494935722 modified "2023-10-15" @default.
• W2494935722 title "Patient-derived xenograft models of colorectal cancer in pre-clinical research: a systematic review" @default.
• W2494935722 cites W1494987922 @default.
• W2494935722 cites W1504814099 @default.
• W2494935722 cites W1572656384 @default.
• W2494935722 cites W1911261107 @default.
• W2494935722 cites W1918204060 @default.
• W2494935722 cites W1969233490 @default.
• W2494935722 cites W1971161974 @default.
• W2494935722 cites W1971386572 @default.
• W2494935722 cites W1972953754 @default.
• W2494935722 cites W1973983272 @default.
• W2494935722 cites W1976326295 @default.
• W2494935722 cites W1977680690 @default.
• W2494935722 cites W1980669422 @default.
• W2494935722 cites W1981421409 @default.
• W2494935722 cites W1984809704 @default.
• W2494935722 cites W1985091939 @default.
• W2494935722 cites W1987443121 @default.
• W2494935722 cites W1992567931 @default.
• W2494935722 cites W1999433592 @default.
• W2494935722 cites W2000053231 @default.
• W2494935722 cites W2001679453 @default.
• W2494935722 cites W2003237825 @default.
• W2494935722 cites W2007513598 @default.
• W2494935722 cites W2008786406 @default.
• W2494935722 cites W2009164582 @default.
• W2494935722 cites W2015270439 @default.
• W2494935722 cites W2016164151 @default.
• W2494935722 cites W2017236031 @default.
• W2494935722 cites W2018634226 @default.
• W2494935722 cites W2027680718 @default.
• W2494935722 cites W2033278321 @default.
• W2494935722 cites W2033751993 @default.
• W2494935722 cites W2034428193 @default.
• W2494935722 cites W2035252444 @default.
• W2494935722 cites W2037764974 @default.
• W2494935722 cites W2038985537 @default.
• W2494935722 cites W2042356721 @default.
• W2494935722 cites W2049069390 @default.
• W2494935722 cites W2052975116 @default.
• W2494935722 cites W2057851402 @default.
• W2494935722 cites W2075298198 @default.
• W2494935722 cites W2080730934 @default.
• W2494935722 cites W2083802683 @default.
• W2494935722 cites W2085257294 @default.
• W2494935722 cites W2087690546 @default.
• W2494935722 cites W2096218887 @default.
• W2494935722 cites W2103875073 @default.
• W2494935722 cites W2107002473 @default.
• W2494935722 cites W2108929503 @default.
• W2494935722 cites W2113506041 @default.
• W2494935722 cites W2113720647 @default.
• W2494935722 cites W2118952409 @default.
• W2494935722 cites W2123303153 @default.
• W2494935722 cites W2123504951 @default.
• W2494935722 cites W2129880070 @default.
• W2494935722 cites W2131408054 @default.
• W2494935722 cites W2131636566 @default.
• W2494935722 cites W2132094713 @default.
• W2494935722 cites W2136043430 @default.
• W2494935722 cites W2137516955 @default.
• W2494935722 cites W2139002359 @default.
• W2494935722 cites W2139132031 @default.
• W2494935722 cites W2140030055 @default.
• W2494935722 cites W2142696104 @default.
• W2494935722 cites W2143465618 @default.
• W2494935722 cites W2144987077 @default.
• W2494935722 cites W2147473016 @default.
• W2494935722 cites W2150942242 @default.
• W2494935722 cites W2156890152 @default.
• W2494935722 cites W2158155247 @default.
• W2494935722 cites W2158257131 @default.
• W2494935722 cites W2162755712 @default.
• W2494935722 cites W2164319752 @default.
• W2494935722 cites W2172077519 @default.
• W2494935722 cites W3022903699 @default.
• W2494935722 cites W4211199921 @default.
• W2494935722 cites W4296816736 @default.
• W2494935722 cites W2063623101 @default.
• W2494935722 doi "https://doi.org/10.18632/oncotarget.11184" @default.
• W2494935722 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5323228" @default.
• W2494935722 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27517155" @default.
• W2494935722 hasPublicationYear "2016" @default.
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