FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2494944008> ?p ?o ?g. }

• W2494944008 endingPage "270" @default.
• W2494944008 startingPage "259" @default.
• W2494944008 abstract "Currently there are no approved vaccines or specific therapies to prevent or treat Zika virus (ZIKV) infection. We interrogated a library of FDA-approved drugs for their ability to block infection of human HuH-7 cells by a newly isolated ZIKV strain (ZIKV MEX_I_7). More than 20 out of 774 tested compounds decreased ZIKV infection in our in vitro screening assay. Selected compounds were further validated for inhibition of ZIKV infection in human cervical, placental, and neural stem cell lines, as well as primary human amnion cells. Established anti-flaviviral drugs (e.g., bortezomib and mycophenolic acid) and others that had no previously known antiviral activity (e.g., daptomycin) were identified as inhibitors of ZIKV infection. Several drugs reduced ZIKV infection across multiple cell types. This study identifies drugs that could be tested in clinical studies of ZIKV infection and provides a resource of small molecules to study ZIKV pathogenesis." @default.
• W2494944008 created "2016-08-23" @default.
• W2494944008 creator A5011122234 @default.
• W2494944008 creator A5019800098 @default.
• W2494944008 creator A5037825451 @default.
• W2494944008 creator A5040485394 @default.
• W2494944008 creator A5048289141 @default.
• W2494944008 creator A5048364031 @default.
• W2494944008 creator A5051477656 @default.
• W2494944008 creator A5055033369 @default.
• W2494944008 creator A5060166195 @default.
• W2494944008 creator A5061652179 @default.
• W2494944008 creator A5063390927 @default.
• W2494944008 creator A5065433595 @default.
• W2494944008 creator A5069169574 @default.
• W2494944008 creator A5073156357 @default.
• W2494944008 creator A5075550999 @default.
• W2494944008 creator A5075582922 @default.
• W2494944008 creator A5075789465 @default.
• W2494944008 creator A5080083293 @default.
• W2494944008 creator A5080652338 @default.
• W2494944008 date "2016-08-01" @default.
• W2494944008 modified "2023-10-14" @default.
• W2494944008 title "A Screen of FDA-Approved Drugs for Inhibitors of Zika Virus Infection" @default.
• W2494944008 cites W1031071957 @default.
• W2494944008 cites W12260993 @default.
• W2494944008 cites W1545235721 @default.
• W2494944008 cites W1818833536 @default.
• W2494944008 cites W1884797475 @default.
• W2494944008 cites W1965936780 @default.
• W2494944008 cites W1967490229 @default.
• W2494944008 cites W1967777408 @default.
• W2494944008 cites W1969528530 @default.
• W2494944008 cites W1969941684 @default.
• W2494944008 cites W1971581267 @default.
• W2494944008 cites W1973619678 @default.
• W2494944008 cites W1975120587 @default.
• W2494944008 cites W1977475475 @default.
• W2494944008 cites W1981910825 @default.
• W2494944008 cites W1988189150 @default.
• W2494944008 cites W1990701251 @default.
• W2494944008 cites W1990847378 @default.
• W2494944008 cites W1991001144 @default.
• W2494944008 cites W1999795482 @default.
• W2494944008 cites W2012188043 @default.
• W2494944008 cites W2016100084 @default.
• W2494944008 cites W2027313042 @default.
• W2494944008 cites W2038451181 @default.
• W2494944008 cites W2039155298 @default.
• W2494944008 cites W2051184011 @default.
• W2494944008 cites W2054405945 @default.
• W2494944008 cites W2061345986 @default.
• W2494944008 cites W2062107099 @default.
• W2494944008 cites W2065276673 @default.
• W2494944008 cites W2065982408 @default.
• W2494944008 cites W2076738925 @default.
• W2494944008 cites W2077334721 @default.
• W2494944008 cites W2090524403 @default.
• W2494944008 cites W2104428288 @default.
• W2494944008 cites W2105570105 @default.
• W2494944008 cites W2117058176 @default.
• W2494944008 cites W2117119827 @default.
• W2494944008 cites W2118512375 @default.
• W2494944008 cites W2127864764 @default.
• W2494944008 cites W2129993409 @default.
• W2494944008 cites W2133250947 @default.
• W2494944008 cites W2138077682 @default.
• W2494944008 cites W2142514218 @default.
• W2494944008 cites W2145586786 @default.
• W2494944008 cites W2151547308 @default.
• W2494944008 cites W2152546486 @default.
• W2494944008 cites W2160300693 @default.
• W2494944008 cites W2163970515 @default.
• W2494944008 cites W2165157662 @default.
• W2494944008 cites W2178567898 @default.
• W2494944008 cites W2179840174 @default.
• W2494944008 cites W2208614289 @default.
• W2494944008 cites W2260741209 @default.
• W2494944008 cites W2265054258 @default.
• W2494944008 cites W2288868071 @default.
• W2494944008 cites W2289704315 @default.
• W2494944008 cites W2292422784 @default.
• W2494944008 cites W2295245778 @default.
• W2494944008 cites W2295355747 @default.
• W2494944008 cites W2311276862 @default.
• W2494944008 cites W2311770845 @default.
• W2494944008 cites W2330564436 @default.
• W2494944008 cites W2336000290 @default.
• W2494944008 cites W2337074877 @default.
• W2494944008 cites W2337135418 @default.
• W2494944008 cites W2338033977 @default.
• W2494944008 cites W2341041396 @default.
• W2494944008 cites W2342837874 @default.
• W2494944008 cites W2343657527 @default.
• W2494944008 cites W2356757232 @default.
• W2494944008 cites W2357313632 @default.
• W2494944008 cites W2384699986 @default.
• W2494944008 cites W2413814731 @default.

• next