Matches in SemOpenAlex for { <https://semopenalex.org/work/W2495005910> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2495005910 endingPage "1941" @default.
- W2495005910 startingPage "1937" @default.
- W2495005910 abstract "In Crohn's disease (CD), rapid response to anti-tumor necrosis factor therapy improves short- and medium-term outcomes, but the relationship between early remission (ER) and long-term remission is unclear.This exploratory analysis of PRECiSE 3 (NCT00160524) assessed whether ER after initiation of certolizumab pegol predicted long-term remission.Patients enrolled in PRECiSE 3 had completed PRECiSE 1 or 2, two randomized placebo-controlled studies for moderate to severe CD, and received open-label certolizumab pegol 400 mg every 4 weeks for a total treatment duration of ≤7.5 years. Time to loss of remission between patients with and without ER (Harvey-Bradshaw Index ≤4 at or before Week 6 of PRECiSE 1 or 2) was compared by log-rank test of Kaplan-Meier estimates.At baseline, patients with (n = 242) and without (n = 148) ER had mean (standard deviation [SD]) durations of CD of 6.8 (6.6) and 7.4 (7.8) years, mean (SD) CD Activity Index scores of 280.3 (53.4) and 311.1 (55.5), with 45.5% and 41.9% of patients having ileocolonic CD, and median C-reactive protein concentrations of 8.0 and 5.0 mg/L, respectively. Median certolizumab pegol plasma concentrations during the first 6 weeks of therapy were similar in both groups. Mean time to loss of remission was significantly longer in patients with versus without ER (2.77 vs. 1.14 years, p < 0.0001).In certolizumab pegol-treated patients with CD, ER appears to be an important predictor of long-term clinical remission. Prospective trials are needed to determine whether ER improves other long-term outcomes." @default.
- W2495005910 created "2016-08-23" @default.
- W2495005910 creator A5024421831 @default.
- W2495005910 creator A5027592480 @default.
- W2495005910 creator A5035961257 @default.
- W2495005910 creator A5037183472 @default.
- W2495005910 creator A5058310461 @default.
- W2495005910 creator A5059435501 @default.
- W2495005910 creator A5083726032 @default.
- W2495005910 date "2016-08-22" @default.
- W2495005910 modified "2023-10-18" @default.
- W2495005910 title "Early remission status predicts long-term outcomes in patients with Crohn’s disease treated with certolizumab pegol" @default.
- W2495005910 cites W1536852940 @default.
- W2495005910 cites W1585033336 @default.
- W2495005910 cites W1594767072 @default.
- W2495005910 cites W1601965618 @default.
- W2495005910 cites W1964785646 @default.
- W2495005910 cites W1968000533 @default.
- W2495005910 cites W1984325421 @default.
- W2495005910 cites W1991966978 @default.
- W2495005910 cites W2003835888 @default.
- W2495005910 cites W2022661087 @default.
- W2495005910 cites W2039439001 @default.
- W2495005910 cites W2102245241 @default.
- W2495005910 cites W2112635226 @default.
- W2495005910 cites W2117465577 @default.
- W2495005910 cites W2127632431 @default.
- W2495005910 cites W2138633359 @default.
- W2495005910 cites W2166360124 @default.
- W2495005910 cites W2168370388 @default.
- W2495005910 cites W2171341132 @default.
- W2495005910 cites W2332730996 @default.
- W2495005910 doi "https://doi.org/10.1080/03007995.2016.1221802" @default.
- W2495005910 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27494777" @default.
- W2495005910 hasPublicationYear "2016" @default.
- W2495005910 type Work @default.
- W2495005910 sameAs 2495005910 @default.
- W2495005910 citedByCount "2" @default.
- W2495005910 countsByYear W24950059102020 @default.
- W2495005910 countsByYear W24950059102022 @default.
- W2495005910 crossrefType "journal-article" @default.
- W2495005910 hasAuthorship W2495005910A5024421831 @default.
- W2495005910 hasAuthorship W2495005910A5027592480 @default.
- W2495005910 hasAuthorship W2495005910A5035961257 @default.
- W2495005910 hasAuthorship W2495005910A5037183472 @default.
- W2495005910 hasAuthorship W2495005910A5058310461 @default.
- W2495005910 hasAuthorship W2495005910A5059435501 @default.
- W2495005910 hasAuthorship W2495005910A5083726032 @default.
- W2495005910 hasConcept C126322002 @default.
- W2495005910 hasConcept C142724271 @default.
- W2495005910 hasConcept C204787440 @default.
- W2495005910 hasConcept C27081682 @default.
- W2495005910 hasConcept C2776215756 @default.
- W2495005910 hasConcept C2779134260 @default.
- W2495005910 hasConcept C2779280984 @default.
- W2495005910 hasConcept C2780132546 @default.
- W2495005910 hasConcept C71924100 @default.
- W2495005910 hasConcept C90924648 @default.
- W2495005910 hasConceptScore W2495005910C126322002 @default.
- W2495005910 hasConceptScore W2495005910C142724271 @default.
- W2495005910 hasConceptScore W2495005910C204787440 @default.
- W2495005910 hasConceptScore W2495005910C27081682 @default.
- W2495005910 hasConceptScore W2495005910C2776215756 @default.
- W2495005910 hasConceptScore W2495005910C2779134260 @default.
- W2495005910 hasConceptScore W2495005910C2779280984 @default.
- W2495005910 hasConceptScore W2495005910C2780132546 @default.
- W2495005910 hasConceptScore W2495005910C71924100 @default.
- W2495005910 hasConceptScore W2495005910C90924648 @default.
- W2495005910 hasIssue "12" @default.
- W2495005910 hasLocation W24950059101 @default.
- W2495005910 hasLocation W24950059102 @default.
- W2495005910 hasOpenAccess W2495005910 @default.
- W2495005910 hasPrimaryLocation W24950059101 @default.
- W2495005910 hasRelatedWork W115503016 @default.
- W2495005910 hasRelatedWork W1543168456 @default.
- W2495005910 hasRelatedWork W1569618141 @default.
- W2495005910 hasRelatedWork W172469162 @default.
- W2495005910 hasRelatedWork W1964785646 @default.
- W2495005910 hasRelatedWork W1970547942 @default.
- W2495005910 hasRelatedWork W2504326190 @default.
- W2495005910 hasRelatedWork W3107358738 @default.
- W2495005910 hasRelatedWork W4253864806 @default.
- W2495005910 hasRelatedWork W2188685377 @default.
- W2495005910 hasVolume "32" @default.
- W2495005910 isParatext "false" @default.
- W2495005910 isRetracted "false" @default.
- W2495005910 magId "2495005910" @default.
- W2495005910 workType "article" @default.