FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2495009504> ?p ?o ?g. }

• W2495009504 endingPage "363" @default.
• W2495009504 startingPage "349" @default.
• W2495009504 abstract "Summary Invasion of hepatocytes by sporozoites is essential for Plasmodium to initiate infection of the mammalian host. The parasite's subsequent intracellular differentiation in the liver is the first developmental step of its mammalian cycle. Despite their biological significance, surprisingly little is known of the signalling pathways required for sporozoite invasion. We report that sporozoite invasion of hepatocytes requires signalling through two second‐messengers – cGMP mediated by the parasite's cGMP‐dependent protein kinase (PKG), and Ca 2+ , mediated by the parasite's calcium‐dependent protein kinase 4 (CDPK4). Sporozoites expressing a mutated form of Plasmodium berghei PKG or carrying a deletion of the CDPK4 gene are defective in invasion of hepatocytes. Using specific and potent inhibitors of Plasmodium PKG and CDPK4, we demonstrate that PKG and CDPK4 are required for sporozoite motility, and that PKG regulates the secretion of TRAP, an adhesin that is essential for motility. Chemical inhibition of PKG decreases parasite egress from hepatocytes by inhibiting either the formation or release of merosomes. In contrast, genetic inhibition of CDPK4 does not significantly decrease the number of merosomes. By revealing the requirement for PKG and CDPK4 in Plasmodium sporozoite invasion, our work enables a better understanding of kinase pathways that act in different Plasmodium stages." @default.
• W2495009504 created "2016-08-23" @default.
• W2495009504 creator A5005944101 @default.
• W2495009504 creator A5008174448 @default.
• W2495009504 creator A5009309168 @default.
• W2495009504 creator A5018835870 @default.
• W2495009504 creator A5024623344 @default.
• W2495009504 creator A5074672579 @default.
• W2495009504 creator A5080458286 @default.
• W2495009504 creator A5083775331 @default.
• W2495009504 creator A5091177557 @default.
• W2495009504 date "2016-08-09" @default.
• W2495009504 modified "2023-10-16" @default.
• W2495009504 title "Invasion of hepatocytes by<i>Plasmodium</i>sporozoites requires cGMP-dependent protein kinase and calcium dependent protein kinase 4" @default.
• W2495009504 cites W1522914336 @default.
• W2495009504 cites W1880787406 @default.
• W2495009504 cites W1923119978 @default.
• W2495009504 cites W1956301473 @default.
• W2495009504 cites W1970339000 @default.
• W2495009504 cites W1973529656 @default.
• W2495009504 cites W1983169756 @default.
• W2495009504 cites W1987368684 @default.
• W2495009504 cites W1990023697 @default.
• W2495009504 cites W1992797356 @default.
• W2495009504 cites W1995636848 @default.
• W2495009504 cites W1996760177 @default.
• W2495009504 cites W1997681499 @default.
• W2495009504 cites W2010769866 @default.
• W2495009504 cites W2012434248 @default.
• W2495009504 cites W2015186773 @default.
• W2495009504 cites W2015784069 @default.
• W2495009504 cites W2016745238 @default.
• W2495009504 cites W2025636478 @default.
• W2495009504 cites W2025676593 @default.
• W2495009504 cites W2026109859 @default.
• W2495009504 cites W2041282815 @default.
• W2495009504 cites W2057830631 @default.
• W2495009504 cites W2060403328 @default.
• W2495009504 cites W2061095849 @default.
• W2495009504 cites W2067517994 @default.
• W2495009504 cites W2080744974 @default.
• W2495009504 cites W2081493247 @default.
• W2495009504 cites W2082990282 @default.
• W2495009504 cites W2087650666 @default.
• W2495009504 cites W2093590217 @default.
• W2495009504 cites W2094725247 @default.
• W2495009504 cites W2097629005 @default.
• W2495009504 cites W2098489572 @default.
• W2495009504 cites W2103812334 @default.
• W2495009504 cites W2104700616 @default.
• W2495009504 cites W2106176044 @default.
• W2495009504 cites W2112091201 @default.
• W2495009504 cites W2112393852 @default.
• W2495009504 cites W2116575985 @default.
• W2495009504 cites W2128509362 @default.
• W2495009504 cites W2139533311 @default.
• W2495009504 cites W2140468443 @default.
• W2495009504 cites W2142106325 @default.
• W2495009504 cites W2156711536 @default.
• W2495009504 cites W2162460181 @default.
• W2495009504 cites W2168908538 @default.
• W2495009504 cites W2171422864 @default.
• W2495009504 cites W2171516424 @default.
• W2495009504 cites W2178730413 @default.
• W2495009504 cites W2243475344 @default.
• W2495009504 cites W2317505741 @default.
• W2495009504 doi "https://doi.org/10.1111/mmi.13466" @default.
• W2495009504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27425827" @default.
• W2495009504 hasPublicationYear "2016" @default.
• W2495009504 type Work @default.
• W2495009504 sameAs 2495009504 @default.
• W2495009504 citedByCount "62" @default.
• W2495009504 countsByYear W24950095042017 @default.
• W2495009504 countsByYear W24950095042018 @default.
• W2495009504 countsByYear W24950095042019 @default.
• W2495009504 countsByYear W24950095042020 @default.
• W2495009504 countsByYear W24950095042021 @default.
• W2495009504 countsByYear W24950095042022 @default.
• W2495009504 countsByYear W24950095042023 @default.
• W2495009504 crossrefType "journal-article" @default.
• W2495009504 hasAuthorship W2495009504A5005944101 @default.
• W2495009504 hasAuthorship W2495009504A5008174448 @default.
• W2495009504 hasAuthorship W2495009504A5009309168 @default.
• W2495009504 hasAuthorship W2495009504A5018835870 @default.
• W2495009504 hasAuthorship W2495009504A5024623344 @default.
• W2495009504 hasAuthorship W2495009504A5074672579 @default.
• W2495009504 hasAuthorship W2495009504A5080458286 @default.
• W2495009504 hasAuthorship W2495009504A5083775331 @default.
• W2495009504 hasAuthorship W2495009504A5091177557 @default.
• W2495009504 hasBestOaLocation W24950095042 @default.
• W2495009504 hasConcept C136764020 @default.
• W2495009504 hasConcept C163235415 @default.
• W2495009504 hasConcept C184235292 @default.
• W2495009504 hasConcept C195794163 @default.
• W2495009504 hasConcept C199217515 @default.
• W2495009504 hasConcept C203014093 @default.
• W2495009504 hasConcept C2777237215 @default.
• W2495009504 hasConcept C2778048844 @default.

• next