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- W249502778 abstract "Abstract Neuroblastoma is the third most common form of cancer to strike children, after brain tumours and leukemia. It is highly diverse and advanced tumours are difficult to treat, with high mortality rates, although some advanced tumours spontaneously regress. Lung Cancer is the most common cancer in the world and a leading cause of cancer related deaths worldwide. It is classified into Small Cell Lung Carcinoma (SCLC) and Non-Small Cell Lung Carcinoma (NSCLC), where SCLC is more aggressive and has a higher mortality rate than NSCLC.Hypoxia is a feature of almost all solid tumours and something both normal and transformed cells have the ability to endure and adapt to. As a tumour outgrows the capacity for its accompanying blood vessels to supply oxygen, hypoxia initially serves to limit the growth of the tumour. However, as the tumour cells adapt to low oxygen pressures they often become more aggressive and prone to metastasize. The Hypoxia Inducible Factor (HIF) proteins are key regulators of the cellular response to hypoxia and if activated, can induce many of the changes that make advanced tumours dangerous and difficult to treat. In this report, we show that the NSCLC cell line U1810 have similar HIF2A and IGF2 mRNA expression patterns as the neuroblastoma cell lines SK-N-BE(2)c and KCN-69n, with low HIF2A and IGF2 expression at 21% oxygen (normoxia) and high expression at 1% oxygen (hypoxia). We also show that the SCLC cell line U1690 and the neuroblastoma cell line IMR-32 have very low expression of HIF2A and IGF2 mRNA at 21% oxygen and 1% oxygen, both at acute and prolonged phases of hypoxia. Despite their different HIF expression patterns, both U1810 and U1690 have a functioning PI3K-AKT pathway, as suggested by the presence of phosphorylated AKT." @default.
- W249502778 created "2016-06-24" @default.
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- W249502778 date "2013-01-01" @default.
- W249502778 modified "2023-09-23" @default.
- W249502778 title "HIF2A and IGF2 in Neuroblastoma and Small Cell Lung Carcinoma" @default.
- W249502778 hasPublicationYear "2013" @default.
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