Matches in SemOpenAlex for { <https://semopenalex.org/work/W2495038862> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2495038862 abstract "Large-conductance, calcium-activated potassium (BK) channels are widely expressed and acquire functional heterogeneity through alternative splicing, auxiliary subunits (β1-4, γ1-4), and posttranslational modifications. An additional mechanism with the potential to alter channel properties is natural genetic variation via single nucleotide polymorphisms (SNPs). Five SNPs in the gene encoding the pore-forming α subunit of BK, Kcnma1, were predicted to have potentially deleterious effects on channel properties. To determine whether these SNPs could alter BK currents, we introduced the SNPs into two human BK variants expressed in HEK293T cells, encoding muscle and brain-type channels (hBKQEERL and hBKVYR, respectively). We found that an autism-linked SNP (A138V), located in the ‘core’ channel intracellular S0-S1 linker, had little effect on current properties, while two non-disease-linked SNPs (C495G and R800W) in the C-terminal gating ring affected the conductance-voltage relationship and kinetics across multiple Ca2+ conditions in the context of both BK variants. Although the conductance-voltage relationships of the hBKQEERL and hBKVYR variants differed across Ca2+ conditions, R800W consistently produced rightward shifts in the V1/2 values, while C495G produced leftward shifts in the V1/2 values. These results suggest that SNP effects are additive in combination with splice variant effects in channel properties and implicate naturally occurring human genetic variation as a potential modulator of BK channel function." @default.
- W2495038862 created "2016-08-23" @default.
- W2495038862 creator A5068294078 @default.
- W2495038862 creator A5069368810 @default.
- W2495038862 creator A5090679062 @default.
- W2495038862 date "2016-02-01" @default.
- W2495038862 modified "2023-09-28" @default.
- W2495038862 title "Effects of Single Nucleotide Polymorphisms (SNPs) on BK K+ Channel Properties" @default.
- W2495038862 doi "https://doi.org/10.1016/j.bpj.2015.11.1518" @default.
- W2495038862 hasPublicationYear "2016" @default.
- W2495038862 type Work @default.
- W2495038862 sameAs 2495038862 @default.
- W2495038862 citedByCount "0" @default.
- W2495038862 crossrefType "journal-article" @default.
- W2495038862 hasAuthorship W2495038862A5068294078 @default.
- W2495038862 hasAuthorship W2495038862A5069368810 @default.
- W2495038862 hasAuthorship W2495038862A5090679062 @default.
- W2495038862 hasBestOaLocation W24950388621 @default.
- W2495038862 hasConcept C104317684 @default.
- W2495038862 hasConcept C12554922 @default.
- W2495038862 hasConcept C135763542 @default.
- W2495038862 hasConcept C149614440 @default.
- W2495038862 hasConcept C151730666 @default.
- W2495038862 hasConcept C153209595 @default.
- W2495038862 hasConcept C174510640 @default.
- W2495038862 hasConcept C185592680 @default.
- W2495038862 hasConcept C194544171 @default.
- W2495038862 hasConcept C2779343474 @default.
- W2495038862 hasConcept C2780989783 @default.
- W2495038862 hasConcept C54355233 @default.
- W2495038862 hasConcept C61144316 @default.
- W2495038862 hasConcept C83743174 @default.
- W2495038862 hasConcept C86803240 @default.
- W2495038862 hasConceptScore W2495038862C104317684 @default.
- W2495038862 hasConceptScore W2495038862C12554922 @default.
- W2495038862 hasConceptScore W2495038862C135763542 @default.
- W2495038862 hasConceptScore W2495038862C149614440 @default.
- W2495038862 hasConceptScore W2495038862C151730666 @default.
- W2495038862 hasConceptScore W2495038862C153209595 @default.
- W2495038862 hasConceptScore W2495038862C174510640 @default.
- W2495038862 hasConceptScore W2495038862C185592680 @default.
- W2495038862 hasConceptScore W2495038862C194544171 @default.
- W2495038862 hasConceptScore W2495038862C2779343474 @default.
- W2495038862 hasConceptScore W2495038862C2780989783 @default.
- W2495038862 hasConceptScore W2495038862C54355233 @default.
- W2495038862 hasConceptScore W2495038862C61144316 @default.
- W2495038862 hasConceptScore W2495038862C83743174 @default.
- W2495038862 hasConceptScore W2495038862C86803240 @default.
- W2495038862 hasLocation W24950388621 @default.
- W2495038862 hasOpenAccess W2495038862 @default.
- W2495038862 hasPrimaryLocation W24950388621 @default.
- W2495038862 hasRelatedWork W1503053719 @default.
- W2495038862 hasRelatedWork W1894020854 @default.
- W2495038862 hasRelatedWork W1967192982 @default.
- W2495038862 hasRelatedWork W1971232871 @default.
- W2495038862 hasRelatedWork W1974175751 @default.
- W2495038862 hasRelatedWork W1983374955 @default.
- W2495038862 hasRelatedWork W1984514898 @default.
- W2495038862 hasRelatedWork W1988124840 @default.
- W2495038862 hasRelatedWork W1991988540 @default.
- W2495038862 hasRelatedWork W1992094157 @default.
- W2495038862 hasRelatedWork W2014359610 @default.
- W2495038862 hasRelatedWork W2019268667 @default.
- W2495038862 hasRelatedWork W2049974379 @default.
- W2495038862 hasRelatedWork W2071568770 @default.
- W2495038862 hasRelatedWork W2095324256 @default.
- W2495038862 hasRelatedWork W2096395994 @default.
- W2495038862 hasRelatedWork W2417531343 @default.
- W2495038862 hasRelatedWork W2786074608 @default.
- W2495038862 hasRelatedWork W2798107342 @default.
- W2495038862 hasRelatedWork W2537659789 @default.
- W2495038862 isParatext "false" @default.
- W2495038862 isRetracted "false" @default.
- W2495038862 magId "2495038862" @default.
- W2495038862 workType "article" @default.