Matches in SemOpenAlex for { <https://semopenalex.org/work/W24951019> ?p ?o ?g. }
- W24951019 endingPage "CMC.S708" @default.
- W24951019 startingPage "CMC.S708" @default.
- W24951019 abstract "Circumstantial evidence suggests that oxidative stress plays a crucial role in the initiation and progression of atherosclerosis, but little is known about the relationship between oxidative stress per se, cholesterol transport and endothelial cell integrity. The aim of the present work is to tackle this issue by treating human umbilical vein endothelial cells (HUVEC) with iron/ascorbate for 4 and 8 hours and by subsequently evaluating the cholesterol flux, the gene expression status of cholesterol transporters, nuclear receptors and adhesion molecules, as well as the cellular adhesion of THP-1 monocytes to HUVEC. The incubation of HUVEC with iron/ascorbate resulted in marked lipid peroxidation as reflected by high malondialdehyde levels, which were reduced by pre-treatment with the antioxidant Trolox. Our experiments could not reveal any modifications in the protein and gene expression of the transporters (ABCA1, SR-BI, LOX-1), the adhesion molecules (VCAM-1, ICAM-1 and E-selectin) and the nuclear receptors (PPARs and LXRs) under the influence of iron/ascorbate. However, oxidative stress enhanced monocyte adhesion to HUVEC, induced the gene expression of ICAM-1, E-selectin and MCP-1, whereas it downregulated eNOS mRNA in the presence of monocytes. Overall, our data suggest that oxidative stress is more harmful in the presence of heterocellular communication between endothelial cells and monocytes." @default.
- W24951019 created "2016-06-24" @default.
- W24951019 creator A5010981339 @default.
- W24951019 creator A5020808506 @default.
- W24951019 creator A5024127357 @default.
- W24951019 creator A5033717234 @default.
- W24951019 creator A5039922554 @default.
- W24951019 creator A5078702171 @default.
- W24951019 creator A5080640564 @default.
- W24951019 date "2008-01-01" @default.
- W24951019 modified "2023-10-16" @default.
- W24951019 title "Effect of Oxidative Stress on the Status of Adhesion Molecules, Nuclear Receptors and Cholesterol Flux in Endothelial Cells: Priming of Monocytes" @default.
- W24951019 cites W1533359222 @default.
- W24951019 cites W1550634958 @default.
- W24951019 cites W1588516858 @default.
- W24951019 cites W1607399348 @default.
- W24951019 cites W1846974702 @default.
- W24951019 cites W1860908381 @default.
- W24951019 cites W1968088754 @default.
- W24951019 cites W1969785040 @default.
- W24951019 cites W1994916925 @default.
- W24951019 cites W2001332055 @default.
- W24951019 cites W2002408287 @default.
- W24951019 cites W2004297047 @default.
- W24951019 cites W2005016263 @default.
- W24951019 cites W2017298257 @default.
- W24951019 cites W2023677185 @default.
- W24951019 cites W2028390550 @default.
- W24951019 cites W2032513433 @default.
- W24951019 cites W2039344988 @default.
- W24951019 cites W2041670522 @default.
- W24951019 cites W2046112813 @default.
- W24951019 cites W2050548878 @default.
- W24951019 cites W2059289901 @default.
- W24951019 cites W2066315645 @default.
- W24951019 cites W2072254145 @default.
- W24951019 cites W2085017133 @default.
- W24951019 cites W2088555845 @default.
- W24951019 cites W2099105972 @default.
- W24951019 cites W2111172134 @default.
- W24951019 cites W2111482014 @default.
- W24951019 cites W2121877708 @default.
- W24951019 cites W2122001410 @default.
- W24951019 cites W2123404136 @default.
- W24951019 cites W2130881449 @default.
- W24951019 cites W2137570167 @default.
- W24951019 cites W2137752048 @default.
- W24951019 cites W2139319526 @default.
- W24951019 cites W2140857791 @default.
- W24951019 cites W2145807969 @default.
- W24951019 cites W2146864851 @default.
- W24951019 cites W2155677898 @default.
- W24951019 cites W2156818917 @default.
- W24951019 cites W2159087408 @default.
- W24951019 cites W2159615817 @default.
- W24951019 cites W2164206876 @default.
- W24951019 cites W2171056569 @default.
- W24951019 cites W3196550503 @default.
- W24951019 doi "https://doi.org/10.4137/cmc.s708" @default.
- W24951019 hasPublicationYear "2008" @default.
- W24951019 type Work @default.
- W24951019 sameAs 24951019 @default.
- W24951019 citedByCount "0" @default.
- W24951019 crossrefType "journal-article" @default.
- W24951019 hasAuthorship W24951019A5010981339 @default.
- W24951019 hasAuthorship W24951019A5020808506 @default.
- W24951019 hasAuthorship W24951019A5024127357 @default.
- W24951019 hasAuthorship W24951019A5033717234 @default.
- W24951019 hasAuthorship W24951019A5039922554 @default.
- W24951019 hasAuthorship W24951019A5078702171 @default.
- W24951019 hasAuthorship W24951019A5080640564 @default.
- W24951019 hasBestOaLocation W249510191 @default.
- W24951019 hasConcept C104317684 @default.
- W24951019 hasConcept C126322002 @default.
- W24951019 hasConcept C1491633281 @default.
- W24951019 hasConcept C16224149 @default.
- W24951019 hasConcept C170493617 @default.
- W24951019 hasConcept C185946421 @default.
- W24951019 hasConcept C2776151105 @default.
- W24951019 hasConcept C2776985958 @default.
- W24951019 hasConcept C2776992346 @default.
- W24951019 hasConcept C2779828298 @default.
- W24951019 hasConcept C2780972559 @default.
- W24951019 hasConcept C2781184567 @default.
- W24951019 hasConcept C55493867 @default.
- W24951019 hasConcept C63932345 @default.
- W24951019 hasConcept C71924100 @default.
- W24951019 hasConcept C85789140 @default.
- W24951019 hasConcept C86339819 @default.
- W24951019 hasConcept C86803240 @default.
- W24951019 hasConcept C95444343 @default.
- W24951019 hasConceptScore W24951019C104317684 @default.
- W24951019 hasConceptScore W24951019C126322002 @default.
- W24951019 hasConceptScore W24951019C1491633281 @default.
- W24951019 hasConceptScore W24951019C16224149 @default.
- W24951019 hasConceptScore W24951019C170493617 @default.
- W24951019 hasConceptScore W24951019C185946421 @default.
- W24951019 hasConceptScore W24951019C2776151105 @default.