FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2495102879> ?p ?o ?g. }

• W2495102879 endingPage "5856" @default.
• W2495102879 startingPage "5845" @default.
• W2495102879 abstract "Abstract Hypoxia is a common feature of solid tumors, which controls multiple aspects of cancer progression. One important function of hypoxia and the hypoxia-inducible factors (HIF) is the maintenance of cancer stem-like cells (CSC), a population of tumor cells that possess stem cell-like properties and drives tumor growth. Among the changes promoted by hypoxia is a metabolic shift resulting in acidification of the tumor microenvironment. Here, we show that glioma hypoxia and acidosis functionally cooperate in inducing HIF transcription factors and CSC maintenance. We found that these effects did not involve the classical PHD/VHL pathway for HIF upregulation, but instead involved the stress-induced chaperone protein HSP90. Genetic or pharmacologic inactivation of HSP90 inhibited the increase in HIF levels and abolished the self-renewal and tumorigenic properties of CSCs induced by acidosis. In clinical specimens of glioma, HSP90 was upregulated in the hypoxic niche and was correlated with a CSC phenotype. Our findings highlight the role of tumor acidification within the hypoxic niche in the regulation of HIF and CSC function through HSP90, with implications for therapeutic strategies to target CSC in gliomas and other hypoxic tumors. Cancer Res; 76(19); 5845–56. ©2016 AACR." @default.
• W2495102879 created "2016-08-23" @default.
• W2495102879 creator A5002992255 @default.
• W2495102879 creator A5006508665 @default.
• W2495102879 creator A5010925883 @default.
• W2495102879 creator A5028732612 @default.
• W2495102879 creator A5028917319 @default.
• W2495102879 creator A5079002531 @default.
• W2495102879 date "2016-10-01" @default.
• W2495102879 modified "2023-10-15" @default.
• W2495102879 title "Acidosis Acts through HSP90 in a PHD/VHL-Independent Manner to Promote HIF Function and Stem Cell Maintenance in Glioma" @default.
• W2495102879 cites W1577277640 @default.
• W2495102879 cites W1578959990 @default.
• W2495102879 cites W1749022239 @default.
• W2495102879 cites W185426278 @default.
• W2495102879 cites W1965849506 @default.
• W2495102879 cites W1972415785 @default.
• W2495102879 cites W1973596980 @default.
• W2495102879 cites W1989259873 @default.
• W2495102879 cites W1990295156 @default.
• W2495102879 cites W1991985021 @default.
• W2495102879 cites W1993104608 @default.
• W2495102879 cites W1995596330 @default.
• W2495102879 cites W1996715681 @default.
• W2495102879 cites W2005868568 @default.
• W2495102879 cites W2011661029 @default.
• W2495102879 cites W2012172048 @default.
• W2495102879 cites W2012353207 @default.
• W2495102879 cites W2013735638 @default.
• W2495102879 cites W2017881797 @default.
• W2495102879 cites W2021777937 @default.
• W2495102879 cites W2022451432 @default.
• W2495102879 cites W2024334459 @default.
• W2495102879 cites W2025183726 @default.
• W2495102879 cites W2027790491 @default.
• W2495102879 cites W2029225014 @default.
• W2495102879 cites W2037785089 @default.
• W2495102879 cites W2039075677 @default.
• W2495102879 cites W2039792930 @default.
• W2495102879 cites W2042216712 @default.
• W2495102879 cites W2046174396 @default.
• W2495102879 cites W2051349300 @default.
• W2495102879 cites W2058106994 @default.
• W2495102879 cites W2060902443 @default.
• W2495102879 cites W2067838946 @default.
• W2495102879 cites W2068050569 @default.
• W2495102879 cites W2071123870 @default.
• W2495102879 cites W2086248882 @default.
• W2495102879 cites W2087377825 @default.
• W2495102879 cites W2101735112 @default.
• W2495102879 cites W2116184358 @default.
• W2495102879 cites W2118604693 @default.
• W2495102879 cites W2119593356 @default.
• W2495102879 cites W2133193034 @default.
• W2495102879 cites W2142057493 @default.
• W2495102879 cites W2148051205 @default.
• W2495102879 cites W2156687584 @default.
• W2495102879 cites W2167795547 @default.
• W2495102879 cites W2985100448 @default.
• W2495102879 doi "https://doi.org/10.1158/0008-5472.can-15-2630" @default.
• W2495102879 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27488520" @default.
• W2495102879 hasPublicationYear "2016" @default.
• W2495102879 type Work @default.
• W2495102879 sameAs 2495102879 @default.
• W2495102879 citedByCount "58" @default.
• W2495102879 countsByYear W24951028792016 @default.
• W2495102879 countsByYear W24951028792017 @default.
• W2495102879 countsByYear W24951028792018 @default.
• W2495102879 countsByYear W24951028792019 @default.
• W2495102879 countsByYear W24951028792020 @default.
• W2495102879 countsByYear W24951028792021 @default.
• W2495102879 countsByYear W24951028792022 @default.
• W2495102879 countsByYear W24951028792023 @default.
• W2495102879 crossrefType "journal-article" @default.
• W2495102879 hasAuthorship W2495102879A5002992255 @default.
• W2495102879 hasAuthorship W2495102879A5006508665 @default.
• W2495102879 hasAuthorship W2495102879A5010925883 @default.
• W2495102879 hasAuthorship W2495102879A5028732612 @default.
• W2495102879 hasAuthorship W2495102879A5028917319 @default.
• W2495102879 hasAuthorship W2495102879A5079002531 @default.
• W2495102879 hasBestOaLocation W24951028791 @default.
• W2495102879 hasConcept C104317684 @default.
• W2495102879 hasConcept C121608353 @default.
• W2495102879 hasConcept C127561419 @default.
• W2495102879 hasConcept C134018914 @default.
• W2495102879 hasConcept C178790620 @default.
• W2495102879 hasConcept C185592680 @default.
• W2495102879 hasConcept C205260736 @default.
• W2495102879 hasConcept C2775932338 @default.
• W2495102879 hasConcept C2776107976 @default.
• W2495102879 hasConcept C2778227246 @default.
• W2495102879 hasConcept C2778553927 @default.
• W2495102879 hasConcept C2779256057 @default.
• W2495102879 hasConcept C28328180 @default.
• W2495102879 hasConcept C2908647359 @default.
• W2495102879 hasConcept C3020616263 @default.
• W2495102879 hasConcept C502942594 @default.
• W2495102879 hasConcept C540031477 @default.

• next