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- W2495138153 abstract "In the late 1960s the introduction of cytosine arabinoside (ara-C) transformed acute myelogenous leukemia (AML) from an incurable to a potentially curable disease. Around the same time clinical research discovered the activity of the anthracycline antibiotic, daunorubicin (DNR), in acute leukemia. Subsequently DNR plus ara-C has provided the backbone of most clinical trials alone or together with other agents such as thioguanine. Cardiac toxicity is dose limiting with DNR at high cumulative doses. Other anthracyclines such as doxorubicin, rubidazone, and idarubicin have been developed with attempts to increase the responsiveness of the leukemia and to decrease the cardiac toxicity. Results of early clinical trials suggest that idarubicin at the dose and schedule studied has a higher response rate than DNR in combination with ara-C. Other agents have been developed which have significant activity in acute myelogenous leukemia. These agents include amsacrine, VP-16, and the topic of this report which will be mitoxantrone.KeywordsAcute LeukemiaAcute Myelogenous LeukemiaSalvage TherapyBlast CrisisRemission InductionThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves." @default.
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- W2495138153 date "1992-01-01" @default.
- W2495138153 modified "2023-09-27" @default.
- W2495138153 title "Mitoxantrone in the Treatment of Acute Leukemias" @default.
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- W2495138153 doi "https://doi.org/10.1007/978-3-642-76591-9_109" @default.
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