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- W2495297725 endingPage "287" @default.
- W2495297725 startingPage "261" @default.
- W2495297725 abstract "Minimizing impurities is generally the first approach to raising a yield. Consistent impurity profiles are needed for APIs destined for human use, and impurities should not exceed the levels seen in the qualifying tox batches. Heterogeneous processing can have benefits and limitations. By understanding the degradation of starting materials the amount of impurities in a process can be controlled. Controlling pH can be a simple and effective way to optimize a process. The addition sequence, duration of addition, and time between additions can be key to developing an effective process. By understanding the degradation of product during a workup the amount of impurities in a process can be controlled. Statistical design of experiments (DoE) and reaction kinetics can provide windows for rapid process development. Continuous processing may be necessary to make more material safely or in high yield due to generation of a reactive intermediate or product. False negative results and false positive results can derail effective process development, and independent, orthogonal analyses are helpful to avoid such pitfalls." @default.
- W2495297725 created "2016-08-23" @default.
- W2495297725 creator A5014999580 @default.
- W2495297725 date "2012-01-01" @default.
- W2495297725 modified "2023-10-18" @default.
- W2495297725 title "Optimizing Organometallic Reactions" @default.
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