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- W2495301664 abstract "Introduction The organochlorine insecticide methoxychlor (MXC) [1,1,1-trichloro-2,2-bis(4-methoxyphenyl) ethane] is a structural analogue of the environmentally persistent compound DDT. Although MXC is biodegradable (1-3) and it exhibits relatively lower acute toxicity in mammals compared with DDT (1), various studies have shown that methoxychlor may elicit estrogenic responses in mammals (4,5) and also wildlife including fish (6,7). Such estrogenic effects of methoxychlor are believed to be caused by the action of its demethylated metabolites (8-10), which are major phase I metabolites catalyzed by the cytochrome P450 monooxygenase system. Therefore, it is important to understand the metabolism of methoxychlor in mammals and also wildlife species. Most of the studies, however, have focused on the phase I metabolic reaction (functionalization reaction) of methoxychlor, but little information is available for methoxychlor phase II metabolism (conjugation reaction). Since the precision-cut tissue slice technique using an automated mechanical tissue slicer (e.g. Krumdieck Tissue Slicer) was introduced," @default.
- W2495301664 created "2016-08-23" @default.
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- W2495301664 date "2005-03-08" @default.
- W2495301664 modified "2023-09-25" @default.
- W2495301664 title "Comparative In Vitro Metabolism of [<sup>14</sup>C]Methoxychlor in Vertebrate Species Using Precision-Cut Liver Slice Technique" @default.
- W2495301664 doi "https://doi.org/10.1021/bk-2005-0899.ch016" @default.
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