Matches in SemOpenAlex for { <https://semopenalex.org/work/W2495302605> ?p ?o ?g. }
- W2495302605 abstract "This chapter describes cellular pathways and molecular events in cardioprotection. Understanding the cellular and molecular mechanisms of cardioprotection is essential in developing new therapies to improve the welfare of so many patients with myocardial diseases. Ischemic preconditioning (IPC) by single or multiple brief nonlethal periods of ischemia and reperfusion protects the heart against a more prolonged ischemic insult, reducing infarct size, and can restore cardiac function and diminish myocardial arrhythmias. This robust form of cardioprotection has been widely documented in animal models, as well as in cardiomyocytes in vitro, and seems to occur in humans in response to balloon angioplasty and angina. IPC has been shown to have an acute and a delayed cardioprotective phase, both involving the activation within the myocyte of specific triggering pathways and mediating signals and end effectors. The chapter presents the complex molecular mechanism and cellular targets of both phases of IPC. A large assortment of drugs has been provided to mimic IPC when either substituted for the preconditioning period or applied at reperfusion." @default.
- W2495302605 created "2016-08-23" @default.
- W2495302605 creator A5022739391 @default.
- W2495302605 date "2007-01-01" @default.
- W2495302605 modified "2023-10-17" @default.
- W2495302605 title "Cellular Pathways and Molecular Events in Cardioprotection" @default.
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