Matches in SemOpenAlex for { <https://semopenalex.org/work/W2495331338> ?p ?o ?g. }
- W2495331338 endingPage "449" @default.
- W2495331338 startingPage "441" @default.
- W2495331338 abstract "This chapter reviews the autoinhibitory mechanisms involved in the regulation of protein kinases and then describe the mechanisms that result in their activation in tumor cells. Finally we discuss the exciting prospect that protein kinase inhibitors will be useful therapeutic agents for the treatment of cancer. Because of their prominent role in tumor progression, protein kinases are promising targets for therapy. Many kinase inhibitors are at various stages of development, but two types are of particular interest. One strategy for inhibiting receptor tyrosine kinase function is the use of anti-receptor antibodies that recognize the ectodomain of the receptor, block ligand binding, and induce receptor endocytosis. Herceptin™ (trastuzumab), a humanized version of a mouse monoclonal antibody against HER2, inhibits the growth of breast cancer cells that overexpress HER2 and has been approved for the treatment of breast cancer patients with HER2-positive tumors. This antibody may act by promoting the c-Cbl-dependent polyubiquitination and degradation of the receptor. A chimeric humanized version of a mouse monoclonal antibody against the EGF receptor (Erbitux™, formerly known as IMC-C225 or Cetuximab) has also been reported to give positive results in clinical trials, but these findings have been questioned, and this antibody has not yet received FDA approval. The other class of drugs under development are small molecule inhibitors that inhibit kinase function." @default.
- W2495331338 created "2016-08-23" @default.
- W2495331338 creator A5012608726 @default.
- W2495331338 date "2003-01-01" @default.
- W2495331338 modified "2023-10-16" @default.
- W2495331338 title "Activation of Oncogenic Protein Kinases" @default.
- W2495331338 cites W1525531613 @default.
- W2495331338 cites W1526536789 @default.
- W2495331338 cites W1556753125 @default.
- W2495331338 cites W1566890736 @default.
- W2495331338 cites W1585894933 @default.
- W2495331338 cites W1592701464 @default.
- W2495331338 cites W1594020010 @default.
- W2495331338 cites W1594706458 @default.
- W2495331338 cites W1622452956 @default.
- W2495331338 cites W1639582946 @default.
- W2495331338 cites W1870003868 @default.
- W2495331338 cites W190702000 @default.
- W2495331338 cites W1926593386 @default.
- W2495331338 cites W1931708823 @default.
- W2495331338 cites W1968572823 @default.
- W2495331338 cites W1969255091 @default.
- W2495331338 cites W1969939692 @default.
- W2495331338 cites W1976197008 @default.
- W2495331338 cites W1977957449 @default.
- W2495331338 cites W1988821060 @default.
- W2495331338 cites W1990085600 @default.
- W2495331338 cites W1991683855 @default.
- W2495331338 cites W1992030386 @default.
- W2495331338 cites W1992185689 @default.
- W2495331338 cites W1992945955 @default.
- W2495331338 cites W1994572080 @default.
- W2495331338 cites W1999447199 @default.
- W2495331338 cites W1999614615 @default.
- W2495331338 cites W2002473468 @default.
- W2495331338 cites W2006522453 @default.
- W2495331338 cites W2007044832 @default.
- W2495331338 cites W2010503112 @default.
- W2495331338 cites W2014397920 @default.
- W2495331338 cites W2015956088 @default.
- W2495331338 cites W2018369441 @default.
- W2495331338 cites W2019573100 @default.
- W2495331338 cites W2019890837 @default.
- W2495331338 cites W2026907934 @default.
- W2495331338 cites W2028415754 @default.
- W2495331338 cites W2032738391 @default.
- W2495331338 cites W2033401763 @default.
- W2495331338 cites W2034269086 @default.
- W2495331338 cites W2036180570 @default.
- W2495331338 cites W2039610291 @default.
- W2495331338 cites W2040616051 @default.
- W2495331338 cites W2049184213 @default.
- W2495331338 cites W2049706987 @default.
- W2495331338 cites W2051506850 @default.
- W2495331338 cites W2051998869 @default.
- W2495331338 cites W2052221882 @default.
- W2495331338 cites W2052912081 @default.
- W2495331338 cites W2056270776 @default.
- W2495331338 cites W2061244362 @default.
- W2495331338 cites W2061580596 @default.
- W2495331338 cites W2065289702 @default.
- W2495331338 cites W2067405360 @default.
- W2495331338 cites W2068151645 @default.
- W2495331338 cites W2072140252 @default.
- W2495331338 cites W2080045298 @default.
- W2495331338 cites W2082706608 @default.
- W2495331338 cites W2088806906 @default.
- W2495331338 cites W2093188317 @default.
- W2495331338 cites W2094957750 @default.
- W2495331338 cites W2095974037 @default.
- W2495331338 cites W2102618729 @default.
- W2495331338 cites W2103002807 @default.
- W2495331338 cites W2114734809 @default.
- W2495331338 cites W2119455657 @default.
- W2495331338 cites W2122883438 @default.
- W2495331338 cites W2128805986 @default.
- W2495331338 cites W2130039540 @default.
- W2495331338 cites W2131174104 @default.
- W2495331338 cites W2138547604 @default.
- W2495331338 cites W2139002843 @default.
- W2495331338 cites W2140490890 @default.
- W2495331338 cites W2142376231 @default.
- W2495331338 cites W2143678301 @default.
- W2495331338 cites W2145202221 @default.
- W2495331338 cites W2148527073 @default.
- W2495331338 cites W2156480395 @default.
- W2495331338 cites W2162525969 @default.
- W2495331338 cites W2163188200 @default.
- W2495331338 cites W2171620774 @default.
- W2495331338 cites W2171797561 @default.
- W2495331338 cites W2312712001 @default.
- W2495331338 cites W39467412 @default.
- W2495331338 cites W45936251 @default.
- W2495331338 cites W2138882303 @default.
- W2495331338 doi "https://doi.org/10.1016/b978-012124546-7/50437-x" @default.
- W2495331338 hasPublicationYear "2003" @default.
- W2495331338 type Work @default.
- W2495331338 sameAs 2495331338 @default.