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- W2495338002 endingPage "712" @default.
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- W2495338002 abstract "This chapter reviews accepted concepts and considers controversial or unsettled elements of parathyroid hormone (PTH) and PTH-related protein (PTHrP) actions. It begins with a discussion of the renal effects of PTH and PTHrP action to provide a framework for understanding their actions on bone. Following this, it deals with calcium and phosphate homeostasis. PTH1R expression, signaling, and regulation in the kidney are also explained. Furthermore, the study provides an understanding of calcium absorption and excretion and phosphate excretion. Recent advances in the understanding of the mechanisms and regulatory actions of PTH and PTHrP on kidney and bone are introduced. Mineral ion homeostasis is regulated primarily by the kidneys, largely through the actions of PTH. PTHrP exerts actions on the kidney that are associated with controlling renal vascular tone, though its physiological role is unsettled. In bone, PTHrP is a major hormonal regulator of bone formation, whereas PTH contributes to postnatal skeletal integrity. Bone and kidney form a storage and regulatory axis that ensures normal growth, development, and multiple tissue and cellular functions that intimately depend on stringent control of intra- and extracellular mineral ion concentrations. This regulation is accomplished principally in the kidneys. This chapter concludes with an explanation of the effects of PTH and PTHrP on bone cells and on the bone." @default.
- W2495338002 created "2016-08-23" @default.
- W2495338002 creator A5013228845 @default.
- W2495338002 creator A5072441929 @default.
- W2495338002 date "2008-01-01" @default.
- W2495338002 modified "2023-09-26" @default.
- W2495338002 title "PTH and PTHrP Actions on Kidney and Bone" @default.
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