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• W2495377703 abstract "Objective: To define the influence of hormonal replacement therapy (HRT) on 24-hour dynamics of blood pressure and vascular stiffness in postmenopausal women with climacteric syndrome. Design and method: The research included 28 postmenopausal women with climacteric syndrome, average age was 52.5 years, average menopause length was not more then 5 years. The incidence of tobacco consumption was 28.6%; 64.3% had stage 1 and 2 arterial hypertension, length was 3 years (antihypertensive therapy was presented as Nifedipine 30–60 mg., in several cases in combination with Indapamide 1,5 mg, duration of therapy at the begining of study reached from 6 to 28 months, it was not changed during the study); 57.1% had metabolic syndrome and 14.3% had contravention of carbohydrate metabolism. At the study entry all women were underwent both clinical and gynecological examination (no contraindications for HRT), 24-hour blood pressure monitoring and examination of vascular stiffness by oscillometric method using MnSDP-2 with BPlab Vasotens. All women were prescribed HRT, containing 1 mg estradiol and 2 mg drospirenone per tablet. The study lasted 16 weeks. Results: After 16 weeks of therapy we identified that mean daily systolic blood pressure (SBP)/diastolic blood pressure (DBP) reduced from 130.1 ± 12.7 to 121.4 ± 7.8/from 82.6 ± 6.7 to 75.7 ± 4.1 mmHg (p < 0.001); average daytime SBP decreased from 135.8 ± 10.3 to 124.0 ± 7.5 mmHg; average daytime DBP decreased from 84.8 ± 5.7 to 78.2 ± 4.8 mmHg (p < 0.001); average SBP at night period decreased from 125.3 ± 17.0 to 116.4 ± 13.3 mmHg (p < 0.05). Studing vascular stiffness we found out significant reducing of Ambulatory arterial stiffness index (AASI) from 0.460 to 0.425 (p < 0.05), pulse pressure decreased from 49.4 to 45.6 mmHg (p < 0.01) and Augmentation index (AIx/AIx-75) from −14.7% to −13.5%/ from −15.5% to −24% (p < 0.05). Conclusions: Hormonal replacement therapy, containing 1 mg estradiol and 2 mg drospirenone has beneficial effects on daily blood pressure level and vascular stiffness in postmenopausal women with climacteric syndrome after 16 weeks." @default.
• W2495377703 created "2016-08-23" @default.
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• W2495377703 date "2016-09-01" @default.
• W2495377703 modified "2023-09-25" @default.
• W2495377703 title "[PP.29.17] THE INFLUENCE OF HORMONAL REPLACEMENT THERAPY ON CARDIOVASCULAR SYSTEM IN POSTMENOPAUSAL WOMEN WITH CLIMACTERIC SYNDROME" @default.
• W2495377703 doi "https://doi.org/10.1097/01.hjh.0000492226.51258.89" @default.
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