Matches in SemOpenAlex for { <https://semopenalex.org/work/W2495387695> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2495387695 endingPage "e104" @default.
- W2495387695 startingPage "e104" @default.
- W2495387695 abstract "Objective: Vascular tone is influenced by release of norepinephrine (NE) from sympathetic nerves and by nitric oxide (NO) released from perivascular neuronal NO synthase (nNOS). nNOS appears a more important physiological determinant of vascular tone than endothelial NO synthase (eNOS), particularly when stimulated by stress. Thus vascular tone is determined mainly by the balance of the two neurally released mediators, NE tending to constrict and NO to dilate vascular smooth muscle. Indirect observations suggest there may be cross-talk between peripheral α-adrenergic receptors and nNOS signalling. Design and method: We therefore examined local forearm vasodilator responses to intra-brachial artery infusion of the non-selective α-adrenergic antagonist phentolamine in the presence and absence of S-methyl-L-thiocitrulline (SMTC), a specific inhibitor of nNOS. Normotensive participants (n = 12, 7 female, mean ± SD age 33 ± 13 years) were studied on two separate occasions in a two-visit single-blind, cross-over study, with each visit separated by at least 7 days. SMTC (0.2 μmol/min, a dose that inhibits vasodilation to mental stress but not to other NO donors or to calcium channel antagonists) on one visit and saline vehicle on the other were co-infused with a rising dose infusion of phentolamine (10, 30 and 100 μg/ml/min). Results: Phentolamine increased forearm blood flow less (from 3.39 ± 0.58 to 6.01 ± 1.10 ml/min/100 ml) when co-infused with SMTC compared to saline vehicle (increase from 3.37 ± 0.45 to 8.74 ± 1.16 ml/min/100 ml, P < 0.05 for difference in blood flow response). Conclusions: These data suggest that peripheral α-adrenergic receptors inhibit nNOS activation, an action likely to potentiate vasoconstrictor responses and to oppose antithrombotic and antiplatelet effects of nNOS-derived NO and which may contribute to nNOS dysfunction in hypertension and in other conditions associated with increased sympathetic activation." @default.
- W2495387695 created "2016-08-23" @default.
- W2495387695 creator A5041125217 @default.
- W2495387695 creator A5041837237 @default.
- W2495387695 creator A5050794885 @default.
- W2495387695 creator A5075056333 @default.
- W2495387695 creator A5082445800 @default.
- W2495387695 creator A5082826312 @default.
- W2495387695 date "2016-09-01" @default.
- W2495387695 modified "2023-09-25" @default.
- W2495387695 title "[OP.8C.08] INTERACTION BETWEEN PERIPHERAL ALPHA-ADRENERGIC RECEPTORS AND NEURONAL NITRIC OXIDE SYNTHASE" @default.
- W2495387695 doi "https://doi.org/10.1097/01.hjh.0000491606.74085.c8" @default.
- W2495387695 hasPublicationYear "2016" @default.
- W2495387695 type Work @default.
- W2495387695 sameAs 2495387695 @default.
- W2495387695 citedByCount "0" @default.
- W2495387695 crossrefType "journal-article" @default.
- W2495387695 hasAuthorship W2495387695A5041125217 @default.
- W2495387695 hasAuthorship W2495387695A5041837237 @default.
- W2495387695 hasAuthorship W2495387695A5050794885 @default.
- W2495387695 hasAuthorship W2495387695A5075056333 @default.
- W2495387695 hasAuthorship W2495387695A5082445800 @default.
- W2495387695 hasAuthorship W2495387695A5082826312 @default.
- W2495387695 hasConcept C120770815 @default.
- W2495387695 hasConcept C126322002 @default.
- W2495387695 hasConcept C134018914 @default.
- W2495387695 hasConcept C158453852 @default.
- W2495387695 hasConcept C170493617 @default.
- W2495387695 hasConcept C2777397205 @default.
- W2495387695 hasConcept C2777622882 @default.
- W2495387695 hasConcept C2778326061 @default.
- W2495387695 hasConcept C2778514916 @default.
- W2495387695 hasConcept C2780253649 @default.
- W2495387695 hasConcept C46762472 @default.
- W2495387695 hasConcept C513476851 @default.
- W2495387695 hasConcept C519581460 @default.
- W2495387695 hasConcept C71924100 @default.
- W2495387695 hasConceptScore W2495387695C120770815 @default.
- W2495387695 hasConceptScore W2495387695C126322002 @default.
- W2495387695 hasConceptScore W2495387695C134018914 @default.
- W2495387695 hasConceptScore W2495387695C158453852 @default.
- W2495387695 hasConceptScore W2495387695C170493617 @default.
- W2495387695 hasConceptScore W2495387695C2777397205 @default.
- W2495387695 hasConceptScore W2495387695C2777622882 @default.
- W2495387695 hasConceptScore W2495387695C2778326061 @default.
- W2495387695 hasConceptScore W2495387695C2778514916 @default.
- W2495387695 hasConceptScore W2495387695C2780253649 @default.
- W2495387695 hasConceptScore W2495387695C46762472 @default.
- W2495387695 hasConceptScore W2495387695C513476851 @default.
- W2495387695 hasConceptScore W2495387695C519581460 @default.
- W2495387695 hasConceptScore W2495387695C71924100 @default.
- W2495387695 hasIssue "Supplement 2" @default.
- W2495387695 hasLocation W24953876951 @default.
- W2495387695 hasOpenAccess W2495387695 @default.
- W2495387695 hasPrimaryLocation W24953876951 @default.
- W2495387695 hasRelatedWork W183467762 @default.
- W2495387695 hasRelatedWork W1969630931 @default.
- W2495387695 hasRelatedWork W1978934760 @default.
- W2495387695 hasRelatedWork W1992074892 @default.
- W2495387695 hasRelatedWork W2004525860 @default.
- W2495387695 hasRelatedWork W2057537203 @default.
- W2495387695 hasRelatedWork W2093919627 @default.
- W2495387695 hasRelatedWork W2109381276 @default.
- W2495387695 hasRelatedWork W2114204950 @default.
- W2495387695 hasRelatedWork W2162889764 @default.
- W2495387695 hasVolume "34" @default.
- W2495387695 isParatext "false" @default.
- W2495387695 isRetracted "false" @default.
- W2495387695 magId "2495387695" @default.
- W2495387695 workType "article" @default.