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- W2495388538 abstract "Through polysaccharide engineering, the composition, structure and porosity of novel glucan carbohydrate microcapsules (Adjuvax) can be controlled to yield sophisticated targeted antigen or drug delivery vehicles. The unique β(1-3)/β(1-6) - linked glucan structure of Adjuvax allows the targeting of antigens to macrophages or neutrophils through interactions with the β-glucan receptor found uniquely on the surface of these cell types. Adjuvax- ligand complexes are formed by physically entrapping or crosslinking the ligand within the β-glucan microcapsule. Sustained release rate is dependent upon microcapsule porosity, ligand molecular weight, degree of Adjuvax - ligand crosslinking, and the rate of carbohydrate biodegradation. Microcapsule porosity is controlled by varying the ratio of the β(1-3)/β(1-6) linkages in the carbohydrate molecule through genetic and process manipulations. The in vitro sustained release rate of entrapped proteins ranged from 1 hour for a 12 kD protein to 6 hours for a 150 kD protein. Adjuvax - ligand crosslinking increased the sustained release rate of the 12 kD protein to greater than 24 hours. Adjuvax coadministered with bovine serum albumin or crosslinked to a series of peptide antigens increased mouse antibody titers, 1,000 fold over antigen only controls. Adjuvax stimulation of antibody titer was equivalent to Complete Freund's Adjuvant (CFA) without the toxicity and histopathology associated with use of CFA. These results suggest that the use of this safe, non-antigenic, newly defined carbohydrate adjuvant may prove useful in new generation vaccines." @default.
- W2495388538 created "2016-08-23" @default.
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- W2495388538 date "1991-08-15" @default.
- W2495388538 modified "2023-09-23" @default.
- W2495388538 title "A New β-Glucan-Based Macrophage-Targeted Adjuvant" @default.
- W2495388538 doi "https://doi.org/10.1021/bk-1991-0469.ch006" @default.
- W2495388538 hasPublicationYear "1991" @default.
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