Matches in SemOpenAlex for { <https://semopenalex.org/work/W2495444602> ?p ?o ?g. }
- W2495444602 endingPage "1947" @default.
- W2495444602 startingPage "1930" @default.
- W2495444602 abstract "An understanding of the pharmacokinetic (PK) and pharmacodynamic (PD) principles that determine response to antimicrobial therapy can provide the clinician with better-informed dosing regimens. Factors influential on antibiotic disposition and clinical outcome are presented, with a focus on the primary site of infection. Techniques to better understand antibiotic PK and optimize PD are acknowledged.PubMed (inception-April 2016) was reviewed for relevant publications assessing antimicrobial exposures within different anatomic locations and clinical outcomes for various infection sites.A limited literature base indicates variable penetration of antibiotics to different target sites of infection, with drug solubility and extent of protein binding providing significant PK influences in addition to the major clearing pathway of the agent. PD indices derived from in vitro studies and animal models determine the optimal magnitude and frequency of dosing regimens for patients. PK/PD modeling and simulation has been shown an efficient means of assessing these PD endpoints against a variety of PK determinants, clarifying the unique effects of infection site and patient characteristics to inform the adequacy of a given antibiotic regimen.Appreciation of the PK properties of an antibiotic and its PD measure of efficacy can maximize the utility of these life-saving drugs. Unfortunately, clinical data remain limited for a number of infection site-antibiotic exposure relationships. Modeling and simulation can bridge preclinical and patient data for the prescription of optimal antibiotic dosing regimens, consistent with the tenets of personalized medicine." @default.
- W2495444602 created "2016-08-23" @default.
- W2495444602 creator A5027004349 @default.
- W2495444602 creator A5031327335 @default.
- W2495444602 creator A5075015951 @default.
- W2495444602 date "2016-09-01" @default.
- W2495444602 modified "2023-09-27" @default.
- W2495444602 title "Pharmacokinetic and Pharmacodynamic Principles of Anti-infective Dosing" @default.
- W2495444602 cites W11063304 @default.
- W2495444602 cites W1641535649 @default.
- W2495444602 cites W176530910 @default.
- W2495444602 cites W1787158122 @default.
- W2495444602 cites W1892816474 @default.
- W2495444602 cites W1905008412 @default.
- W2495444602 cites W1950543547 @default.
- W2495444602 cites W1965789860 @default.
- W2495444602 cites W1966004252 @default.
- W2495444602 cites W1967088772 @default.
- W2495444602 cites W1969477911 @default.
- W2495444602 cites W1969762322 @default.
- W2495444602 cites W1971251009 @default.
- W2495444602 cites W1972470346 @default.
- W2495444602 cites W1977578039 @default.
- W2495444602 cites W1981048436 @default.
- W2495444602 cites W1982374887 @default.
- W2495444602 cites W1982462000 @default.
- W2495444602 cites W1982910325 @default.
- W2495444602 cites W1983076976 @default.
- W2495444602 cites W1984002075 @default.
- W2495444602 cites W1986375294 @default.
- W2495444602 cites W1988114782 @default.
- W2495444602 cites W1988482538 @default.
- W2495444602 cites W1989071137 @default.
- W2495444602 cites W1991718331 @default.
- W2495444602 cites W1995887867 @default.
- W2495444602 cites W1996134595 @default.
- W2495444602 cites W1997009415 @default.
- W2495444602 cites W1998410651 @default.
- W2495444602 cites W1998853564 @default.
- W2495444602 cites W2004431245 @default.
- W2495444602 cites W2005519201 @default.
- W2495444602 cites W2005891936 @default.
- W2495444602 cites W2005987292 @default.
- W2495444602 cites W2009434440 @default.
- W2495444602 cites W2010066166 @default.
- W2495444602 cites W2010587136 @default.
- W2495444602 cites W2011312924 @default.
- W2495444602 cites W2015821083 @default.
- W2495444602 cites W2015984063 @default.
- W2495444602 cites W2019988983 @default.
- W2495444602 cites W2022568543 @default.
- W2495444602 cites W2028401089 @default.
- W2495444602 cites W2032447526 @default.
- W2495444602 cites W2035298668 @default.
- W2495444602 cites W2039304356 @default.
- W2495444602 cites W2039922575 @default.
- W2495444602 cites W2044710513 @default.
- W2495444602 cites W2045439329 @default.
- W2495444602 cites W2045721684 @default.
- W2495444602 cites W2046385323 @default.
- W2495444602 cites W2046547277 @default.
- W2495444602 cites W2048047136 @default.
- W2495444602 cites W2048390434 @default.
- W2495444602 cites W2048961294 @default.
- W2495444602 cites W2050496243 @default.
- W2495444602 cites W2051367912 @default.
- W2495444602 cites W2052264066 @default.
- W2495444602 cites W2053980008 @default.
- W2495444602 cites W2054319595 @default.
- W2495444602 cites W2055577302 @default.
- W2495444602 cites W2056396129 @default.
- W2495444602 cites W2056612376 @default.
- W2495444602 cites W2056954418 @default.
- W2495444602 cites W2057226149 @default.
- W2495444602 cites W2059275495 @default.
- W2495444602 cites W2060495363 @default.
- W2495444602 cites W2060563399 @default.
- W2495444602 cites W2060706736 @default.
- W2495444602 cites W2062495428 @default.
- W2495444602 cites W2064710851 @default.
- W2495444602 cites W2067034394 @default.
- W2495444602 cites W2067130929 @default.
- W2495444602 cites W2068149021 @default.
- W2495444602 cites W2068489935 @default.
- W2495444602 cites W2068657553 @default.
- W2495444602 cites W2070828665 @default.
- W2495444602 cites W2073595001 @default.
- W2495444602 cites W2078982708 @default.
- W2495444602 cites W2079691262 @default.
- W2495444602 cites W2082321986 @default.
- W2495444602 cites W2085809094 @default.
- W2495444602 cites W2086406927 @default.
- W2495444602 cites W2092672763 @default.
- W2495444602 cites W2093814712 @default.
- W2495444602 cites W2093849401 @default.
- W2495444602 cites W2094918324 @default.
- W2495444602 cites W2096914614 @default.
- W2495444602 cites W2097326548 @default.