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- W2495481636 abstract "Influenza A virus-specific cytotoxic T lym- phocytes (CTL) capable of lysing cells infected with any influ- enza A virus (cross-reactive CTL) constitute a major por- tion of the host CTL response to influenza. The viral nucleo- protein (NP), a major internal virion structural protein, has been implicated as a possible target antigen for cross-reactive CTL. To directly examine CTL recognition of NP, a vaccinia virus recombinant containing a DNA copy of an influenza A virus NP gene was constructed. We found that murine cells infected with this virus were efficiently lysed in a major histo- compatibility complex-restricted manner by cross-reactive CTL populations obtained by immunization with a variety of influenza A virus subtypes. In addition, the recombinant vac- cinia virus containing the PR8 NP gene was able to both stimu- late and prime for a vigorous secondary cross-reactive CTL response. Significantly, splenocytes from mice primed by in- oculation with the recombinant vaccinia virus containing the PR8 NP gene could be stimulated by influenza A viruses of all three major human subtypes. Finally, unlabeled target compe- tition experiments suggest that NP is a major, but not the sole, viral target antigen recognized by cross-reactive CTL." @default.
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- W2495481636 date "2016-01-01" @default.
- W2495481636 modified "2023-09-27" @default.
- W2495481636 title "Influenza A virus nucleoprotein is a major target antigen for cross- reactive anti-influenza A virus cytotoxic T lymphocytes (vaccinia virus vector/influenza vaccine/internal viral protein/cell surface expression/cellular defense mechanism)" @default.
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