Matches in SemOpenAlex for { <https://semopenalex.org/work/W2495494313> ?p ?o ?g. }
- W2495494313 endingPage "1167" @default.
- W2495494313 startingPage "1157" @default.
- W2495494313 abstract "An association of gallbladder carcinoma with cholelithiasis suggests that chronic inflammation may modulate tumorigenesis and/or progression of the carcinoma. An enhanced expression of cyclooxygenase-2 (COX-2) is observed frequently in advanced carcinomas of gastrointestinal tracts, which in turn suggests that potentiated arachidonate metabolism may play a crucial role in tumor biology. In the present study, the expression levels of COX-2 and prostaglandin E receptor subtypes were determined in 16 cases of gallbladder carcinomas of different depths of invasion (pT1 3, pT2 2, pT3 4, and pT4 7) to determine the role of arachidonate metabolism in tumor growth and progression. The mRNA levels of COX-2 were increased significantly in pT3 and pT4 carcinomas compared with the levels in pT1 and pT2 carcinomas. Immunohistochemistry and in situ hybridization revealed the existence of COX-2 mRNA and protein in both the cancerous epithelia and adjacent stroma of pT1-pT4 carcinomas. Only in pT3 and pT4 carcinomas was intense expression of COX-2 observed in the adjacent stroma. The tissue concentration of PGE2 was significantly increased in pT3 and pT4 carcinomas. The mRNAs of PGE receptor subtypes EP2, EP3, and EP4 were amplified in pT1-pT4 gallbladder carcinomas, in which their mRNAs and EP4 protein were expressed mostly in the cancerous epithelia. Treatment with a specific EP4 agonist, as well as PGE2 but not EP2 and EP3 agonists, up-regulated the expression of c-fos, an induced growth response gene, and increased colony formation. In advanced gallbladder carcinoma, enhanced expression of COX-2 is observed in the adjacent stroma rather than in the cancerous epithelia, and the stroma is a potent source of PG synthesis. In epithelial-stromal interactions, the increased PGE2 synthesis in the adjacent stroma and its biological effect via EP4 on the carcinoma cells may contribute to tumor growth and progression of gallbladder carcinoma." @default.
- W2495494313 created "2016-08-23" @default.
- W2495494313 creator A5002276017 @default.
- W2495494313 creator A5005877279 @default.
- W2495494313 creator A5010074467 @default.
- W2495494313 creator A5014507709 @default.
- W2495494313 creator A5017304406 @default.
- W2495494313 creator A5021360652 @default.
- W2495494313 creator A5036189941 @default.
- W2495494313 creator A5045371125 @default.
- W2495494313 creator A5047785115 @default.
- W2495494313 creator A5053545534 @default.
- W2495494313 creator A5073396662 @default.
- W2495494313 creator A5082569020 @default.
- W2495494313 date "2002-04-01" @default.
- W2495494313 modified "2023-09-25" @default.
- W2495494313 title "Expressions of Cyclooxygenase-2 and Prostaglandin E-Receptors in Carcinoma of the Gallbladder" @default.
- W2495494313 cites W1496912415 @default.
- W2495494313 cites W1506285409 @default.
- W2495494313 cites W1506887248 @default.
- W2495494313 cites W1513419514 @default.
- W2495494313 cites W1550686374 @default.
- W2495494313 cites W1557741015 @default.
- W2495494313 cites W1585634514 @default.
- W2495494313 cites W1597826703 @default.
- W2495494313 cites W1648593433 @default.
- W2495494313 cites W1685016018 @default.
- W2495494313 cites W1766737321 @default.
- W2495494313 cites W1775749144 @default.
- W2495494313 cites W1928411162 @default.
- W2495494313 cites W1970523811 @default.
- W2495494313 cites W1978052764 @default.
- W2495494313 cites W1980569429 @default.
- W2495494313 cites W1987257842 @default.
- W2495494313 cites W1987970465 @default.
- W2495494313 cites W1998050886 @default.
- W2495494313 cites W1998456001 @default.
- W2495494313 cites W2004488298 @default.
- W2495494313 cites W2005221636 @default.
- W2495494313 cites W2005319899 @default.
- W2495494313 cites W2005823432 @default.
- W2495494313 cites W2006386734 @default.
- W2495494313 cites W2021415747 @default.
- W2495494313 cites W2022794999 @default.
- W2495494313 cites W2031652451 @default.
- W2495494313 cites W2033000482 @default.
- W2495494313 cites W2035758011 @default.
- W2495494313 cites W2037656993 @default.
- W2495494313 cites W2037687479 @default.
- W2495494313 cites W2045272862 @default.
- W2495494313 cites W2046345325 @default.
- W2495494313 cites W2046501054 @default.
- W2495494313 cites W2049977066 @default.
- W2495494313 cites W2051686420 @default.
- W2495494313 cites W2056237481 @default.
- W2495494313 cites W2056635601 @default.
- W2495494313 cites W2059183932 @default.
- W2495494313 cites W2063144963 @default.
- W2495494313 cites W2074210119 @default.
- W2495494313 cites W2075522151 @default.
- W2495494313 cites W2077492124 @default.
- W2495494313 cites W2082095075 @default.
- W2495494313 cites W2087224686 @default.
- W2495494313 cites W2087744847 @default.
- W2495494313 cites W2091054988 @default.
- W2495494313 cites W2094402172 @default.
- W2495494313 cites W2107574924 @default.
- W2495494313 cites W2113069845 @default.
- W2495494313 cites W2113683216 @default.
- W2495494313 cites W2114589635 @default.
- W2495494313 cites W2115293226 @default.
- W2495494313 cites W2134812217 @default.
- W2495494313 cites W2135938816 @default.
- W2495494313 cites W2148907720 @default.
- W2495494313 cites W2232934670 @default.
- W2495494313 cites W2286535834 @default.
- W2495494313 cites W2398709771 @default.
- W2495494313 cites W2400498591 @default.
- W2495494313 cites W2424257540 @default.
- W2495494313 cites W2502134830 @default.
- W2495494313 cites W2162230360 @default.
- W2495494313 hasPublicationYear "2002" @default.
- W2495494313 type Work @default.
- W2495494313 sameAs 2495494313 @default.
- W2495494313 citedByCount "0" @default.
- W2495494313 crossrefType "journal-article" @default.
- W2495494313 hasAuthorship W2495494313A5002276017 @default.
- W2495494313 hasAuthorship W2495494313A5005877279 @default.
- W2495494313 hasAuthorship W2495494313A5010074467 @default.
- W2495494313 hasAuthorship W2495494313A5014507709 @default.
- W2495494313 hasAuthorship W2495494313A5017304406 @default.
- W2495494313 hasAuthorship W2495494313A5021360652 @default.
- W2495494313 hasAuthorship W2495494313A5036189941 @default.
- W2495494313 hasAuthorship W2495494313A5045371125 @default.
- W2495494313 hasAuthorship W2495494313A5047785115 @default.
- W2495494313 hasAuthorship W2495494313A5053545534 @default.
- W2495494313 hasAuthorship W2495494313A5073396662 @default.
- W2495494313 hasAuthorship W2495494313A5082569020 @default.