FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2495518794> ?p ?o ?g. }

• W2495518794 abstract "Purpose: Radioimmunotherapy delivered by radiometal immunoconjugates and followed by marrow support is dose limited by deposition of radioactivity in normal organs. To increase elimination of radioactivity from the liver and body and, thus, minimize hepatic radiation dose, a peptide having a specific cathepsin B cleavage site was placed between the radiometal chelate DOTA (1,4,7,10-tetraazacyclododecane- N , N ′, N ″, N ‴-tetraacetic acid) and the monoclonal antibody m170, and the comparative pharmacokinetics was evaluated in prostate cancer patients.Experimental Design: 111In-DOTA-2IT-m170 and 111In-DOTA-peptide-(GGGF)-m170, representing the same monoclonal antibody and chelate with and without the cleavable linkage, were studied in comparable groups of prostate cancer patients (17 with In-2IT-BAD-m170 and 8 with In-DOTA-peptide-m170). Pharmacokinetics over 7 days, calculated yttrium-90 radiation dosimetry, therapeutic index, and projected maximum tolerated injected yttrium-90 dose were evaluated.Results: The radioimmunoconjugates pharmacokinetics and calculated tumor and normal organ absorbed radiation dose (rads/mCi) were similar, except for a significant decrease in the mean dose to the liver (31%; P < 0.01) and lungs (31%; P < 0.01) with the DOTA-peptide immunoconjugates. Because mean tumor dose was not statistically different, this peptide linkage provided a significant increase in the therapeutic index for this tumor targeting radiopharmaceutical. If marrow support is adequate, the radiation dose historically tolerated by normal organs other than marrow would allow a 30% increase in the administered dose, resulting in a mean dose of 9500 rads to metastatic prostate cancer." @default.
• W2495518794 created "2016-08-23" @default.
• W2495518794 creator A5012058776 @default.
• W2495518794 creator A5027594758 @default.
• W2495518794 creator A5038808449 @default.
• W2495518794 creator A5043106959 @default.
• W2495518794 creator A5044505402 @default.
• W2495518794 creator A5046589665 @default.
• W2495518794 creator A5056231833 @default.
• W2495518794 creator A5061018141 @default.
• W2495518794 creator A5071249418 @default.
• W2495518794 creator A5075799959 @default.
• W2495518794 creator A5080748223 @default.
• W2495518794 date "2003-09-01" @default.
• W2495518794 modified "2023-09-24" @default.
• W2495518794 title "Enhanced Therapeutic Index of Radioimmunotherapy (RIT) in Prostate Cancer Patients" @default.
• W2495518794 cites W1183586821 @default.
• W2495518794 cites W1565781015 @default.
• W2495518794 cites W1965649272 @default.
• W2495518794 cites W1983847288 @default.
• W2495518794 cites W1986508172 @default.
• W2495518794 cites W2002569266 @default.
• W2495518794 cites W2010768817 @default.
• W2495518794 cites W2026293359 @default.
• W2495518794 cites W2032904685 @default.
• W2495518794 cites W2042369848 @default.
• W2495518794 cites W2042603322 @default.
• W2495518794 cites W2048640269 @default.
• W2495518794 cites W2049348498 @default.
• W2495518794 cites W2062728450 @default.
• W2495518794 cites W2074544671 @default.
• W2495518794 cites W2082323151 @default.
• W2495518794 cites W2083647376 @default.
• W2495518794 cites W2092172351 @default.
• W2495518794 cites W2093329885 @default.
• W2495518794 cites W2097512974 @default.
• W2495518794 cites W2114139604 @default.
• W2495518794 cites W2127901889 @default.
• W2495518794 cites W2133957468 @default.
• W2495518794 cites W2180066093 @default.
• W2495518794 cites W2395580562 @default.
• W2495518794 cites W2398136903 @default.
• W2495518794 cites W2430194433 @default.
• W2495518794 cites W2464502417 @default.
• W2495518794 cites W2764964315 @default.
• W2495518794 cites W2794522676 @default.
• W2495518794 cites W2998090421 @default.
• W2495518794 hasPublicationYear "2003" @default.
• W2495518794 type Work @default.
• W2495518794 sameAs 2495518794 @default.
• W2495518794 citedByCount "0" @default.
• W2495518794 crossrefType "journal-article" @default.
• W2495518794 hasAuthorship W2495518794A5012058776 @default.
• W2495518794 hasAuthorship W2495518794A5027594758 @default.
• W2495518794 hasAuthorship W2495518794A5038808449 @default.
• W2495518794 hasAuthorship W2495518794A5043106959 @default.
• W2495518794 hasAuthorship W2495518794A5044505402 @default.
• W2495518794 hasAuthorship W2495518794A5046589665 @default.
• W2495518794 hasAuthorship W2495518794A5056231833 @default.
• W2495518794 hasAuthorship W2495518794A5061018141 @default.
• W2495518794 hasAuthorship W2495518794A5071249418 @default.
• W2495518794 hasAuthorship W2495518794A5075799959 @default.
• W2495518794 hasAuthorship W2495518794A5080748223 @default.
• W2495518794 hasConcept C112705442 @default.
• W2495518794 hasConcept C121608353 @default.
• W2495518794 hasConcept C126322002 @default.
• W2495518794 hasConcept C159654299 @default.
• W2495518794 hasConcept C178790620 @default.
• W2495518794 hasConcept C185592680 @default.
• W2495518794 hasConcept C197404232 @default.
• W2495518794 hasConcept C19831878 @default.
• W2495518794 hasConcept C203014093 @default.
• W2495518794 hasConcept C2776146153 @default.
• W2495518794 hasConcept C2779931791 @default.
• W2495518794 hasConcept C2780035454 @default.
• W2495518794 hasConcept C2780192828 @default.
• W2495518794 hasConcept C2989005 @default.
• W2495518794 hasConcept C542903549 @default.
• W2495518794 hasConcept C71924100 @default.
• W2495518794 hasConcept C98274493 @default.
• W2495518794 hasConceptScore W2495518794C112705442 @default.
• W2495518794 hasConceptScore W2495518794C121608353 @default.
• W2495518794 hasConceptScore W2495518794C126322002 @default.
• W2495518794 hasConceptScore W2495518794C159654299 @default.
• W2495518794 hasConceptScore W2495518794C178790620 @default.
• W2495518794 hasConceptScore W2495518794C185592680 @default.
• W2495518794 hasConceptScore W2495518794C197404232 @default.
• W2495518794 hasConceptScore W2495518794C19831878 @default.
• W2495518794 hasConceptScore W2495518794C203014093 @default.
• W2495518794 hasConceptScore W2495518794C2776146153 @default.
• W2495518794 hasConceptScore W2495518794C2779931791 @default.
• W2495518794 hasConceptScore W2495518794C2780035454 @default.
• W2495518794 hasConceptScore W2495518794C2780192828 @default.
• W2495518794 hasConceptScore W2495518794C2989005 @default.
• W2495518794 hasConceptScore W2495518794C542903549 @default.
• W2495518794 hasConceptScore W2495518794C71924100 @default.
• W2495518794 hasConceptScore W2495518794C98274493 @default.
• W2495518794 hasIssue "10" @default.
• W2495518794 hasLocation W24955187941 @default.
• W2495518794 hasOpenAccess W2495518794 @default.

• next