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• W2495586513 abstract "Adolescence is an evolutionarily conserved developmental period, with neural circuits and behaviors contributing to the detection, procurement, and receipt of rewards bearing similarity across species. Studies with laboratory animals suggest that adolescence is typified by a “reward-centric” phenotype—an increased sensitivity to rewards relative to adults. In contrast, adolescent rodents are reportedly less sensitive to the aversive properties of many drugs and naturally aversive stimuli. Alterations within the mesocorticolimbic dopamine and endocannabinoid systems likely contribute to an adolescent reward-sensitive, yet aversion-resistant, phenotype. Although early hypotheses postulated that developmental changes in dopaminergic circuitry would result in a “reward deficiency” syndrome, evidence now suggests the opposite: that adolescents are uniquely poised to seek out hedonic stimuli, experience greater “pleasure” from rewards, and consume rewarding stimuli in excess. Future studies that more clearly define the role of specific brain regions and neurotransmitter systems in the expression of behaviors toward reward- and aversive-related cues and stimuli are necessary to more fully understand an adolescent-proclivity for and vulnerability to rewards and drugs of potential abuse." @default.
• W2495586513 created "2016-08-23" @default.
• W2495586513 creator A5027532580 @default.
• W2495586513 date "2016-11-01" @default.
• W2495586513 modified "2023-10-09" @default.
• W2495586513 title "Commentary on the Special Issue on the Adolescent Brain: Incentive-based striving and the adolescent brain" @default.
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• W2495586513 doi "https://doi.org/10.1016/j.neubiorev.2016.06.018" @default.
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