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- W2495597284 abstract "Abstract Brain stimulation in children requires consideration of the unique biology of the immature brain, and insights into molecular and synaptic distinctions between the developing and mature brain come largely from preclinical experiments in rodents. While the published literature contains few examples of brain stimulation in immature animals, an extensive library of rodent neurodevelopmental research can contribute to the design of pediatric brain stimulation protocols. In particular, preclinical studies identify that GABA-mediated inhibition is reduced and glutamate-mediated excitation is enhanced in the developing brain. These observations, coupled with susceptibility of children to seizures, raise a safety concern in pediatrics. Similarly, capacities for synaptic plasticity differ with age, and warrant consideration in brain stimulation protocol design. Also, beyond differences attributable to age, prevalent neurodevelopmental syndromes, such as epilepsy and autism spectrum disorders, are associated with dysmature brain biology, and thus aspects of brain immaturity should be considered even in some older subjects." @default.
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- W2495597284 date "2016-01-01" @default.
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- W2495597284 title "Insights Into Pediatric Brain Stimulation Protocols From Preclinical Research" @default.
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