FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2495600458> ?p ?o ?g. }

• W2495600458 endingPage "817" @default.
• W2495600458 startingPage "809" @default.
• W2495600458 abstract "Rho kinase (ROCK) has been implicated in physiological and pathophysiological processes, including regulation of vascular function. ROCK signaling is thought to be a critical contributor to cardiovascular disease, including hypertension and effects of angiotensin II (Ang II). Two isoforms of ROCK (1 and 2) have been identified and are expressed in vascular cells. In this study, we examined the importance of ROCK2 in relation to vessel function using several models and a novel inhibitor of ROCK2. First, incubation of carotid arteries with the direct RhoA activator CN-03 or Ang II impaired endothelium-dependent relaxation by ≈40% to 50% ( P <0.05) without altering endothelium-independent relaxation. Both CN-03- and Ang II–induced endothelial dysfunction was prevented by Y-27632 (an inhibitor of both ROCK isoforms) or the selective ROCK2 inhibitor SLX-2119. In contrast, SLX-2119 had little effect on contraction of carotid arteries to receptor-mediated agonists (serotonin, phenylephrine, vasopressin, or U46619). Second, in basilar arteries, SLX-2119 inhibited constriction to Ang II by ≈90% without significantly affecting responses to serotonin or KCl. Third, in isolated pressurized brain parenchymal arterioles, SLX-2119 inhibited myogenic tone in a concentration-dependent manner (eg, 1 μmol/L SLX-2119 dilated by 79±4%). Finally, SLX-2119 dilated small pial arterioles in vivo, an effect that was augmented by inhibition of nitric oxide synthase. These findings suggest that ROCK2 has major, but heterogeneous, effects on function of endothelium and vascular muscle. The data support the concept that aberrant ROCK2 signaling may be a key contributor to select aspects of large and small vessel disease, including Ang II–induced endothelial dysfunction." @default.
• W2495600458 created "2016-08-23" @default.
• W2495600458 creator A5002508178 @default.
• W2495600458 creator A5030469285 @default.
• W2495600458 creator A5052669455 @default.
• W2495600458 creator A5052680663 @default.
• W2495600458 creator A5055613709 @default.
• W2495600458 date "2016-09-01" @default.
• W2495600458 modified "2023-10-16" @default.
• W2495600458 title "Heterogeneous Impact of ROCK2 on Carotid and Cerebrovascular Function" @default.
• W2495600458 cites W1540025214 @default.
• W2495600458 cites W1647404354 @default.
• W2495600458 cites W1818978286 @default.
• W2495600458 cites W1875323678 @default.
• W2495600458 cites W1956617330 @default.
• W2495600458 cites W1967134185 @default.
• W2495600458 cites W1971175888 @default.
• W2495600458 cites W1972140533 @default.
• W2495600458 cites W1988760873 @default.
• W2495600458 cites W1997623655 @default.
• W2495600458 cites W2011317373 @default.
• W2495600458 cites W2012666904 @default.
• W2495600458 cites W2013548753 @default.
• W2495600458 cites W2015973293 @default.
• W2495600458 cites W2016955748 @default.
• W2495600458 cites W2018784274 @default.
• W2495600458 cites W2036472881 @default.
• W2495600458 cites W2052750950 @default.
• W2495600458 cites W2078096259 @default.
• W2495600458 cites W2078616546 @default.
• W2495600458 cites W2081383439 @default.
• W2495600458 cites W2082217738 @default.
• W2495600458 cites W2092335200 @default.
• W2495600458 cites W2095854297 @default.
• W2495600458 cites W2099309899 @default.
• W2495600458 cites W2100740244 @default.
• W2495600458 cites W2105633235 @default.
• W2495600458 cites W2108116605 @default.
• W2495600458 cites W2111256272 @default.
• W2495600458 cites W2113975153 @default.
• W2495600458 cites W2114630275 @default.
• W2495600458 cites W2118411978 @default.
• W2495600458 cites W2123621202 @default.
• W2495600458 cites W2124380794 @default.
• W2495600458 cites W2128017045 @default.
• W2495600458 cites W2138742704 @default.
• W2495600458 cites W2139383758 @default.
• W2495600458 cites W2140621953 @default.
• W2495600458 cites W2142776639 @default.
• W2495600458 cites W2149194612 @default.
• W2495600458 cites W2149196587 @default.
• W2495600458 cites W2153092699 @default.
• W2495600458 cites W2154894697 @default.
• W2495600458 cites W2156413973 @default.
• W2495600458 cites W2181108437 @default.
• W2495600458 cites W2208777145 @default.
• W2495600458 cites W2280768757 @default.
• W2495600458 cites W2302035974 @default.
• W2495600458 cites W2343823212 @default.
• W2495600458 cites W2409612189 @default.
• W2495600458 cites W3015786815 @default.
• W2495600458 cites W4247904703 @default.
• W2495600458 doi "https://doi.org/10.1161/hypertensionaha.116.07430" @default.
• W2495600458 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4982851" @default.
• W2495600458 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27432870" @default.
• W2495600458 hasPublicationYear "2016" @default.
• W2495600458 type Work @default.
• W2495600458 sameAs 2495600458 @default.
• W2495600458 citedByCount "23" @default.
• W2495600458 countsByYear W24956004582014 @default.
• W2495600458 countsByYear W24956004582017 @default.
• W2495600458 countsByYear W24956004582018 @default.
• W2495600458 countsByYear W24956004582019 @default.
• W2495600458 countsByYear W24956004582020 @default.
• W2495600458 countsByYear W24956004582021 @default.
• W2495600458 countsByYear W24956004582022 @default.
• W2495600458 crossrefType "journal-article" @default.
• W2495600458 hasAuthorship W2495600458A5002508178 @default.
• W2495600458 hasAuthorship W2495600458A5030469285 @default.
• W2495600458 hasAuthorship W2495600458A5052669455 @default.
• W2495600458 hasAuthorship W2495600458A5052680663 @default.
• W2495600458 hasAuthorship W2495600458A5055613709 @default.
• W2495600458 hasBestOaLocation W24956004581 @default.
• W2495600458 hasConcept C120770815 @default.
• W2495600458 hasConcept C126322002 @default.
• W2495600458 hasConcept C134018914 @default.
• W2495600458 hasConcept C185592680 @default.
• W2495600458 hasConcept C201800478 @default.
• W2495600458 hasConcept C2776048814 @default.
• W2495600458 hasConcept C2776992346 @default.
• W2495600458 hasConcept C2777093181 @default.
• W2495600458 hasConcept C2777952589 @default.
• W2495600458 hasConcept C2779331819 @default.
• W2495600458 hasConcept C55493867 @default.
• W2495600458 hasConcept C62478195 @default.
• W2495600458 hasConcept C71924100 @default.
• W2495600458 hasConcept C84393581 @default.
• W2495600458 hasConceptScore W2495600458C120770815 @default.

• next