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• W2495688515 abstract "246 Objectives To assess the feasibility and potential clinical benefit of next generation digital photon counting PET detector technology (dPET) to facilitate high definition and/or ultra-high definition PET imaging in patients with malignant and metastatic lung lesions. Methods A next-generation, best in class time-of-flight resolution, digital PET/CT system (Vereos) is being used to prospectively image oncology patients in an ongoing clinical trial and compare the achieved imaging characteristics, by intra-individual comparison, with standard of care conventional time-of-flight photomultiplier tube-based detector PET/CT (cPET) (Gemini). The dPET system has a best in class timing resolution of 325 ps vs. 550 ps for the cPET/CT system. Standard cPET imaging was performed in 20 patients with malignant/metastatic lung lesions using a target 481 MBq FDG dose 75 min p.i. with investigational dPET imaging being performed either at ~55 min p.i. or ~95 min p.i. All other imaging acquisition aspects were kept identical. dPET images were reconstructed using time-of-flight with different voxel lengths 4 mm (standard definition), 2 mm (high definition), and 1 mm (ultra-high definition) and compared with standard definition time-of-flight cPET images. Visual and quantitative assessment was performed by a three reader panel independently to evaluate overall image quality, lesion detectability, diagnostic confidence of lesion characterization, and quality of background activity. Results All 20 dPET/CT studies were rated to be of evaluable image quality with the highest image quality scores given to the ultra-high definition dPET reconstructions. In all cases, dPET produced better image quality for the qualitative and quantitative assessment of malignant/metastatic lung lesions compared with cPET. High definition dPET enabled better delineation and improved detection of small lung lesions when compared with cPET and this was even further improved using ultra-high definition reconstructions. The most notable difference were observed for lesions Conclusions 18F-FDG PET imaging of malignant/metastatic pulmonary disease burden is essential for accurate oncologic staging and patient management. While there are already obvious advantages using standard definition reconstruction in dPET imaging compared to cPET, our findings demonstrate an exciting clinical potential of routine high- and ultra-high definition dPET imaging to markedly improve lesion detectability in a variety of pulmonary lesions (especially for lesions ≤ 15mm). The observed capabilities of the digital photon counting PET technology will likely drive new paradigm-shifting precision nuclear medicine practices further leveraged by low radiopharmaceutical doses and faster image acquisition times to achieve improved quantitative accuracy, diagnostic confidence and staging for oncology patients." @default.
• W2495688515 created "2016-08-23" @default.
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• W2495688515 date "2016-05-01" @default.
• W2495688515 modified "2023-09-28" @default.
• W2495688515 title "Precision Nuclear Medicine Enabled by Ultra-High Definition PET: Improved Lesion Detectability Using Digital PET Technology in Patients with Malignant/metastatic Lung Lesions" @default.
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