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• W2495730383 abstract "The performance of an action relies on the initiation and execution of appropriate movement sequences. Two basal ganglia pathways have been classically hypothesized to regulate this process via opposing roles in movement facilitation and suppression. By using a series of state-dependent optogenetic manipulations, we dissected the contributions of each pathway and found that both the direct striatonigral pathway and the indirect striatopallidal pathway are necessary for smooth initiation and the execution of learned action sequences. Optogenetic inhibition or stimulation of each pathway before sequence initiation increased the latency for initiation: manipulations of the striatonigral pathway activity slowed action initiation, and those of the striatopallidal pathway aborted action initiation. The inhibition of each pathway after initiation also impaired ongoing execution. Furthermore, the subtle activation of striatonigral neurons sustained the performance of learned sequences, while striatopallidal manipulations aborted ongoing performance. These results suggest a supportive versus permissive model, where patterns of coordinated activity, rather than the relative amount of activity in these pathways, regulate movement initiation and execution." @default.
• W2495730383 created "2016-08-23" @default.
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• W2495730383 date "2016-07-01" @default.
• W2495730383 modified "2023-10-14" @default.
• W2495730383 title "Complementary Contributions of Striatal Projection Pathways to Action Initiation and Execution" @default.
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• W2495730383 doi "https://doi.org/10.1016/j.cell.2016.06.032" @default.
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