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- W2495756980 endingPage "425" @default.
- W2495756980 startingPage "417" @default.
- W2495756980 abstract "This chapter focuses on the relation between various cardiac diseases and pharmacology of the cardiac Na + –Ca 2+ exchanger, which is the main player of the Ca 2+ extrusion in cardiac myocytes. The canine cardiac Na + –Ca 2+ exchanger (NCX1) has 970 amino acids with a molecular mass of 110 kDa. The overexpression of the Na + –Ca 2+ exchanger reduces the postischemic recovery of cardiac contractile function measured by the left ventricular pressure and energy metabolites and the Na + –Ca 2+ exchanger may play a role in ischemia/reperfusion injury. This exacerbation of ischemia/reperfusion injury by overexpression of the Na + –Ca 2+ exchanger can be overcome partially by female-specific hormones such as estrogen. Na + –Ca 2+ exchanger mRNA in hypothyroid myocardium is elevated more than twofold compared to euthyroid rats. Unlike digitalis for the Na + –K + pump and tetrodotoxin for Na + channels, no specific inhibitor has yet been found for the Na + –Ca 2+ exchanger. However, various compounds including polypeptides and isotheourea derivatives have been demonstrated to inhibit the exchanger. The levels of mRNA, protein, and function of the Na + –Ca 2+ exchanger change dramatically during development, postnatal stages, and aging. The changes are also prominent in various pathological conditions of the heart and the changes occur rapidly." @default.
- W2495756980 created "2016-08-23" @default.
- W2495756980 creator A5059199772 @default.
- W2495756980 date "2001-01-01" @default.
- W2495756980 modified "2023-10-16" @default.
- W2495756980 title "Cardiac Na+–Ca2+ Exchanger: Pathophysiology and Pharmacology" @default.
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- W2495756980 doi "https://doi.org/10.1016/b978-012656975-9/50024-9" @default.
- W2495756980 hasPublicationYear "2001" @default.