FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2495789718> ?p ?o ?g. }

• W2495789718 endingPage "1306" @default.
• W2495789718 startingPage "1299" @default.
• W2495789718 abstract "Blood oligosaccharides are attached to many proteins after translation, forming glycoproteins. Glycosylation refers to an enzyme-mediated modification that alters protein function, for example, their life span or their interactions with other proteins (1). By contrast, glycation refers to a monosaccharide (usually glucose) attaching nonenzymatically to the amino group of a protein. Glycated hemoglobin is formed by the condensation of glucose with select amino acid residues, commonly lysine, in hemoglobin to form an unstable Schiff base (aldimine, pre-HbA1c) (Fig. 1). The Schiff base may dissociate or may undergo an Amadori rearrangement to form a stable ketoamine.Figure 1 Formation of glycated protein. A reversible interaction between a primary amino group (depicted as NH2) of a protein and the carbonyl group of d-glucose yields a labile intermediate, called a Schiff base. This can undergo a slow and spontaneous Amadori rearrangement to form a stable ketoamine. HbA1c is formed if glucose attaches to the N-terminal valine of the β-chain of hemoglobin. If the glucose attaches to proteins in the plasma, fructosamine or glycated albumin results. RBC, red blood cell.Glycated hemoglobin, particularly HbA1c, has for decades been widely incorporated into the management (and, more recently, the diagnosis) of patients with diabetes. An important attribute is that glycation occurs continuously over the lifetime of the protein, so the concentration of the glycated protein reflects the average blood glucose value over a period of time. This contrasts with the measurement of blood glucose, which reveals the glucose concentration at the instant blood is sampled and which is acutely altered by multiple factors such as hormones, illness, food ingestion, and exercise (2). While HbA1c is by far the most extensively used—and studied—glycated protein (2–4), other glycated proteins that have been evaluated in clinical studies include fructosamine, glycated albumin, and …" @default.
• W2495789718 created "2016-08-23" @default.
• W2495789718 creator A5015223159 @default.
• W2495789718 creator A5022779552 @default.
• W2495789718 creator A5053998736 @default.
• W2495789718 date "2016-07-12" @default.
• W2495789718 modified "2023-10-16" @default.
• W2495789718 title "Role of Glycated Proteins in the Diagnosis and Management of Diabetes: Research Gaps and Future Directions" @default.
• W2495789718 cites W112354868 @default.
• W2495789718 cites W1492385092 @default.
• W2495789718 cites W1535971274 @default.
• W2495789718 cites W1569048146 @default.
• W2495789718 cites W1593781427 @default.
• W2495789718 cites W1629736006 @default.
• W2495789718 cites W1694482919 @default.
• W2495789718 cites W1752045965 @default.
• W2495789718 cites W177049054 @default.
• W2495789718 cites W1890065335 @default.
• W2495789718 cites W1896242392 @default.
• W2495789718 cites W1899531259 @default.
• W2495789718 cites W1923494636 @default.
• W2495789718 cites W1964962793 @default.
• W2495789718 cites W1966234811 @default.
• W2495789718 cites W1985342881 @default.
• W2495789718 cites W1987849653 @default.
• W2495789718 cites W1988687859 @default.
• W2495789718 cites W1989986279 @default.
• W2495789718 cites W1995835243 @default.
• W2495789718 cites W2006356353 @default.
• W2495789718 cites W2008463780 @default.
• W2495789718 cites W2013180631 @default.
• W2495789718 cites W2019609793 @default.
• W2495789718 cites W2020468377 @default.
• W2495789718 cites W2021818151 @default.
• W2495789718 cites W2032236555 @default.
• W2495789718 cites W2032738179 @default.
• W2495789718 cites W2037141143 @default.
• W2495789718 cites W2038216402 @default.
• W2495789718 cites W2041477088 @default.
• W2495789718 cites W2042130085 @default.
• W2495789718 cites W2042320787 @default.
• W2495789718 cites W2043801853 @default.
• W2495789718 cites W2044437167 @default.
• W2495789718 cites W2046705708 @default.
• W2495789718 cites W2048816594 @default.
• W2495789718 cites W2054016650 @default.
• W2495789718 cites W2054398296 @default.
• W2495789718 cites W2070340796 @default.
• W2495789718 cites W2072070798 @default.
• W2495789718 cites W2074794423 @default.
• W2495789718 cites W2077255033 @default.
• W2495789718 cites W2081901990 @default.
• W2495789718 cites W2083856205 @default.
• W2495789718 cites W2091977778 @default.
• W2495789718 cites W2100861855 @default.
• W2495789718 cites W2102127536 @default.
• W2495789718 cites W2103860004 @default.
• W2495789718 cites W2107524932 @default.
• W2495789718 cites W2109819974 @default.
• W2495789718 cites W2110911105 @default.
• W2495789718 cites W2113071059 @default.
• W2495789718 cites W2115371188 @default.
• W2495789718 cites W2115745636 @default.
• W2495789718 cites W2128247875 @default.
• W2495789718 cites W2135517124 @default.
• W2495789718 cites W2136497849 @default.
• W2495789718 cites W2138453733 @default.
• W2495789718 cites W2138685848 @default.
• W2495789718 cites W2143642628 @default.
• W2495789718 cites W2146875600 @default.
• W2495789718 cites W2150651436 @default.
• W2495789718 cites W2152932258 @default.
• W2495789718 cites W2153605160 @default.
• W2495789718 cites W2153819826 @default.
• W2495789718 cites W2153916083 @default.
• W2495789718 cites W2154134110 @default.
• W2495789718 cites W2157316662 @default.
• W2495789718 cites W2157828221 @default.
• W2495789718 cites W2160251169 @default.
• W2495789718 cites W2160635731 @default.
• W2495789718 cites W2161893186 @default.
• W2495789718 cites W2162478392 @default.
• W2495789718 cites W2163348221 @default.
• W2495789718 cites W2166731438 @default.
• W2495789718 cites W2167798032 @default.
• W2495789718 cites W2168939438 @default.
• W2495789718 cites W2169921638 @default.
• W2495789718 cites W2171294019 @default.
• W2495789718 cites W2188846692 @default.
• W2495789718 cites W2213727046 @default.
• W2495789718 cites W2271771390 @default.
• W2495789718 cites W2279983270 @default.
• W2495789718 cites W2314997733 @default.
• W2495789718 cites W2333288977 @default.
• W2495789718 cites W2461279011 @default.
• W2495789718 cites W2481518965 @default.
• W2495789718 cites W2491582447 @default.
• W2495789718 cites W2607031541 @default.

• next