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- W2495921698 abstract "CoQ10 is a highly hydrophobic molecule that has been suggested to sits between lipid acyl chains and carries electrons between the enzyme complexes I, II, and III of mitochondrial respiratory chain. It is also reported to alter lateral organization and dynamics of cell membranes to ultimately affect wide range of cellular functions. MPotential mechanism of action of CoQ10 is a function of its incorporation, miscibility, and organization in lipid membranes and this knowledge is central to optimize its use as therapeutic agent. Herein, we use lipid monolayer at air-water interface as a model system to measure CoQ10-lipid interactions and performed two set of measurements. In the first set, lipid membranes with varying concentration of CoQ10 were laterally compressed to measure CoQ10 miscibility and lateral organization. In the second set, membranes at varying packing density were deposited and CoQ10 was injected in proximity to measure its rate of incorporation. Our results demonstrate that CoQ10 has intrinsic nature to selectively incorporate only into lipid membranes with lower packing density and is excluded by membranes at higher packing density. Data also indicate that CoQ10-lipid mixing is non-ideal and CoQ10 presence in lipid membranes is biphasic. This work suggests that large portion of exogenous CoQ10 may not be soluble in lipid membranes and can make its own domain to affect the dynamics and organization cellular membranes. This work provides detailed insight into CoQ10-lipid interactions demonstrating the pleiotropic effects of exogenous CoQ10 on cells." @default.
- W2495921698 created "2016-08-23" @default.
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- W2495921698 date "2016-02-01" @default.
- W2495921698 modified "2023-09-30" @default.
- W2495921698 title "Selective Association of CoQ10 with low Density Lipid Membranes" @default.
- W2495921698 doi "https://doi.org/10.1016/j.bpj.2015.11.2222" @default.
- W2495921698 hasPublicationYear "2016" @default.
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