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- W2496005131 abstract "The origin of this meeting was a rather good dinner in King’s College Cambridge, at which Charlie Loke, Ashley Moffett, Barry Keverne, Azim Surani and myself got together, and it occurred to us that the trophoblast as a tissue was shamefully neglected. Since the definition of the word ‘trophoblast’ clearly means ‘original feeding tissue’ it is perhaps appropriate that the meeting had its origins in a good dinner! Because I have spent a lot of time looking at sections of mouse implantation, seeing the giant mouse trophoblast cells, I have always found trophoblast rather scary. These cells are huge: they are so big they can be seen with the naked eye. In sections they seem to engulf the uterine epithelium and then they engulf the stromal cells. They are very aggressive cells, but they do a remarkable job. Those primary trophoblast cells are directly responsible for the very explosive growth that occurs in mouse implantation during gastrulation. It has been estimated that from the inner cell mass of the 3-day blastocyst (i.e. 3–4 days post coitum (dpc)) up to the 7-day embryo there is a more than 500-fold increase in tissue volume. This is all due to the yolk sac placenta, which does a remarkable job in nourishing and supporting this explosive growth. At 8 days the allantois is growing: it hasn’t quite reached the chorion, so we don’t have a chorioallantoic placenta, but it is the chorioallantoic placenta which is in a way more remarkable because this supports the entire human fetal growth up to full term – in most cases, fortunately, rather successfully. Animals of course eat their placentas and derive considerable nutritional benefit from doing so. This is rare in humans, but I believe recipes have been published. The chorioallantoic placenta has certainly been a source of wonder in many parts of the world for centuries. I have read in Maureen Young’s book (Young 2001) that the Balinese, for example, wash the placenta in perfumed water after birth, wrap it in a cloth and then bury it on the threshold of the family home in a carefully" @default.
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- W2496005131 date "2011-01-01" @default.
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- W2496005131 title "Chair’s introduction" @default.
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