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- W2496016855 abstract "Overt or subtle generalized status epilepticus is a syndrome reflecting a focal or diffuse cerebral dysfunction. Its management is urgent and difficult: the diagnosis must be firmly established, seizures and other clinical and biological factors that may worsen cerebral dysfunction controlled, aetiology identified and treated. Definition of status epilepticus varies among authors, which impedes generalization of the results of the clinical trials and their acceptation by physicians. Although the first line treatment, which must include prolonged action antiepileptics, is rather well codified, difficulties persist to apply the detailed predefined management protocols. The electroencephalogram is underused, whereas it is sometimes absolutely required for diagnosis purpose (elimination of a factitious status, hypoxic-ischaemic encephalopathy, detection of a subtle generalized status epilepticus) or therapeutic purpose (rational management of refractory convulsive status epilepticus). Hypoxic-ischaemic encephalopathy, often confused with subtle generalized status epilepticus, needs to be better characterized especially its electroencephalographic patterns. First-line treatment is not consistently successful in terminating the seizures and more effective treatments are needed, particularly for refractory convulsive status epilepticus. These treatments will require rigorous evaluation through prospective controlled trials. To gain further insight into the factors that bear on the prognosis of CSE, prospective studies using standardised treatments and patient stratification on age and aetiologies are needed. Functional outcome remains poorly assessed. © 2004 Societe de reanimation de langue francaise. Publie par Elsevier SAS. Tous droits reserves. Mots cles : Etat de mal epileptique ; Antiepileptiques ; EEG ; Pronostic ; Soins intensifs" @default.
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- W2496016855 date "2004-01-01" @default.
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- W2496016855 title "États de mal convulsifs généralisés francs et larvés de l'adulte : avancées et perspectives Overt and subtle generalized convulsive status epilepticus: advances and prospects" @default.
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